CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccine
In the present study the effect of the locally produced genetic adjuvant of ginea pig specific CpG-motif-containing oligodeoxynucleotide (CpG-ODN) in an inactivated FMD virus vaccine was evaluated. Boosting the ginea pigs with FMD vaccine along with CpG-ODN adjuvant produced relatively higher ratio...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Razi Vaccine and Serum Research Institute
2010-01-01
|
| Series: | Archives of Razi Institute |
| Subjects: | |
| Online Access: | http://www.archrazi.com/browse.php?a_id=144&sid=1&slc_lang=en |
| _version_ | 1818834481975394304 |
|---|---|
| author | Morshedi, A. Daghighi, M. Mahravani, H. |
| author_facet | Morshedi, A. Daghighi, M. Mahravani, H. |
| author_sort | Morshedi, A. |
| collection | DOAJ |
| description | In the present study the effect of the locally produced genetic adjuvant of ginea pig specific CpG-motif-containing oligodeoxynucleotide (CpG-ODN) in an inactivated FMD virus vaccine was evaluated. Boosting the ginea pigs with FMD vaccine along with CpG-ODN adjuvant produced relatively higher ratio (5-fold) of FMDV-specific IgG2a / IgG1 than those vaccinated in the absence of CpG-ODN. The neutralizing antibody (NA) titer induced by FMD vaccine along with CpG-ODN adjuvant was significantly higher (8-fold) than NA titer induced by the classical FMD vaccine in Alum adjuvant. The titer of NA and virus clearance from serum was consistently and significantly higher in animals primed with FMD vaccine and boosted by CpG-ODN than the classical FMD vaccine. The results of this study showed the potential of CpG-ODN as a genetic adjuvant to FMD vaccine in the development of Th1 responses. |
| first_indexed | 2024-12-19T02:35:31Z |
| format | Article |
| id | doaj.art-71f8c3169b4c4ceea279ad524a36c4d0 |
| institution | Directory Open Access Journal |
| issn | 0365-3439 2008-9872 |
| language | English |
| last_indexed | 2024-12-19T02:35:31Z |
| publishDate | 2010-01-01 |
| publisher | Razi Vaccine and Serum Research Institute |
| record_format | Article |
| series | Archives of Razi Institute |
| spelling | doaj.art-71f8c3169b4c4ceea279ad524a36c4d02022-12-21T20:39:27ZengRazi Vaccine and Serum Research InstituteArchives of Razi Institute0365-34392008-98722010-01-0165117CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccineMorshedi, A.Daghighi, M.Mahravani, H.In the present study the effect of the locally produced genetic adjuvant of ginea pig specific CpG-motif-containing oligodeoxynucleotide (CpG-ODN) in an inactivated FMD virus vaccine was evaluated. Boosting the ginea pigs with FMD vaccine along with CpG-ODN adjuvant produced relatively higher ratio (5-fold) of FMDV-specific IgG2a / IgG1 than those vaccinated in the absence of CpG-ODN. The neutralizing antibody (NA) titer induced by FMD vaccine along with CpG-ODN adjuvant was significantly higher (8-fold) than NA titer induced by the classical FMD vaccine in Alum adjuvant. The titer of NA and virus clearance from serum was consistently and significantly higher in animals primed with FMD vaccine and boosted by CpG-ODN than the classical FMD vaccine. The results of this study showed the potential of CpG-ODN as a genetic adjuvant to FMD vaccine in the development of Th1 responses.http://www.archrazi.com/browse.php?a_id=144&sid=1&slc_lang=enFMD vaccineCpG-ODNAdjuvantGinea pig |
| spellingShingle | Morshedi, A. Daghighi, M. Mahravani, H. CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccine Archives of Razi Institute FMD vaccine CpG-ODN Adjuvant Ginea pig |
| title | CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccine |
| title_full | CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccine |
| title_fullStr | CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccine |
| title_full_unstemmed | CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccine |
| title_short | CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccine |
| title_sort | cpg dna enhancement the immune elicited as adjuvant of foot and mouth disease vaccine |
| topic | FMD vaccine CpG-ODN Adjuvant Ginea pig |
| url | http://www.archrazi.com/browse.php?a_id=144&sid=1&slc_lang=en |
| work_keys_str_mv | AT morshedia cpgdnaenhancementtheimmuneelicitedasadjuvantoffootandmouthdiseasevaccine AT daghighim cpgdnaenhancementtheimmuneelicitedasadjuvantoffootandmouthdiseasevaccine AT mahravanih cpgdnaenhancementtheimmuneelicitedasadjuvantoffootandmouthdiseasevaccine |