Antiviral Ranpirnase TMR-001 Inhibits Rabies Virus Release and Cell-to-Cell Infection In Vitro

Antiviral Ranpirnase TMR-001 Inhibits Rabies Virus Release and Cell-to-Cell Infection In Vitro

Currently, no rabies virus-specific antiviral drugs are available. Ranpirnase has strong antitumor and antiviral properties associated with its ribonuclease activity. TMR-001, a proprietary bulk drug substance solution of ranpirnase, was evaluated against rabies virus in three cell types: mouse neur...

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Bibliographic Details
Main Authors: Todd G. Smith, Felix R. Jackson, Clint N. Morgan, William C. Carson, Brock E. Martin, Nadia Gallardo-Romero, James A. Ellison, Lauren Greenberg, Thomas Hodge, Luis Squiquera, Jamie Sulley, Victoria A. Olson, Christina L. Hutson
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Viruses
Subjects:
rabies virus
lyssavirus
antiviral
ranpirnase tmr-001
onconase
hamster
Online Access:https://www.mdpi.com/1999-4915/12/2/177

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