The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia
Dysfunctional top-down pain modulation is a hallmark of fibromyalgia (FM) and physical exercise is a cornerstone in FM treatment. The aim of this study was to explore the effects of a 15-week intervention of strengthening exercises, twice per week, supervised by a physiotherapist, on exercise-induce...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Neurobiology of Pain |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452073X23000016 |
| _version_ | 1827940551465369600 |
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| author | Monika Löfgren Angelica Sandström Indre Bileviciute-Ljungar Kaisa Mannerkorpi Björn Gerdle Malin Ernberg Peter Fransson Eva Kosek |
| author_facet | Monika Löfgren Angelica Sandström Indre Bileviciute-Ljungar Kaisa Mannerkorpi Björn Gerdle Malin Ernberg Peter Fransson Eva Kosek |
| author_sort | Monika Löfgren |
| collection | DOAJ |
| description | Dysfunctional top-down pain modulation is a hallmark of fibromyalgia (FM) and physical exercise is a cornerstone in FM treatment. The aim of this study was to explore the effects of a 15-week intervention of strengthening exercises, twice per week, supervised by a physiotherapist, on exercise-induced hypoalgesia (EIH) and cerebral pain processing in FM patients and healthy controls (HC). FM patients (n = 59) and HC (n = 39) who completed the exercise intervention as part of a multicenter study were examined at baseline and following the intervention. Following the exercise intervention, FM patients reported a reduction of pain intensity, fibromyalgia severity and depression. Reduced EIH was seen in FM patients compared to HC at baseline and no improvement of EIH was seen following the 15-week resistance exercise intervention in either group. Furthermore, a subsample (Stockholm site: FM n = 18; HC n = 19) was also examined with functional magnetic resonance imaging (fMRI) during subjectively calibrated thumbnail pressure pain stimulations at baseline and following intervention. A significant main effect of exercise (post > pre) was observed both in FM patients and HC, in pain-related brain activation within left dorsolateral prefrontal cortex and caudate, as well as increased functional connectivity between caudate and occipital lobe bordering cerebellum (driven by the FM patients). In conclusion, the results indicate that 15-week resistance exercise affect pain-related processing within the cortico-striatal-occipital networks (involved in motor control and cognition), rather than directly influencing top-down descending pain inhibition. In alignment with this, exercise-induced hypoalgesia remained unaltered. |
| first_indexed | 2024-03-13T09:11:00Z |
| format | Article |
| id | doaj.art-71fab07995554de7bb1b0a251cca7dd2 |
| institution | Directory Open Access Journal |
| issn | 2452-073X |
| language | English |
| last_indexed | 2024-03-13T09:11:00Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Pain |
| spelling | doaj.art-71fab07995554de7bb1b0a251cca7dd22023-05-27T04:26:18ZengElsevierNeurobiology of Pain2452-073X2023-01-0113100114The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesiaMonika Löfgren0Angelica Sandström1Indre Bileviciute-Ljungar2Kaisa Mannerkorpi3Björn Gerdle4Malin Ernberg5Peter Fransson6Eva Kosek7Department of Clinical Sciences, Karolinska Institutet and Department of Rehabilitation Medicine, Danderyd Hospital, Stockholm SE-182 88, SwedenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm SE-171 77, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm SE-171 78, Sweden; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USADepartment of Clinical Sciences, Karolinska Institutet and Department of Rehabilitation Medicine, Danderyd Hospital, Stockholm SE-182 88, SwedenInstitute of Neuroscience and Physiology, Department of Health and Rehabilitation, Physiotherapy Unit, Sahlgrenska Academy, Gothenburg University, Gothenburg SE- 413 90, SwedenPain and Rehabilitation Centre, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping SE-581 83, SwedenDepartment of Dental Medicine, Karolinska Institutet and Scandinavian Centre for Orofacial Neurosciences, Huddinge SE-141 04, SwedenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm SE-171 77, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm SE-171 78, SwedenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm SE-171 77, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm SE-171 78, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala SE- 752 36, Sweden; Corresponding author at: Department of Clinical Neuroscience, Karolinska Institutet, Nobels väg 9, Stockholm SE-171 77, Sweden.Dysfunctional top-down pain modulation is a hallmark of fibromyalgia (FM) and physical exercise is a cornerstone in FM treatment. The aim of this study was to explore the effects of a 15-week intervention of strengthening exercises, twice per week, supervised by a physiotherapist, on exercise-induced hypoalgesia (EIH) and cerebral pain processing in FM patients and healthy controls (HC). FM patients (n = 59) and HC (n = 39) who completed the exercise intervention as part of a multicenter study were examined at baseline and following the intervention. Following the exercise intervention, FM patients reported a reduction of pain intensity, fibromyalgia severity and depression. Reduced EIH was seen in FM patients compared to HC at baseline and no improvement of EIH was seen following the 15-week resistance exercise intervention in either group. Furthermore, a subsample (Stockholm site: FM n = 18; HC n = 19) was also examined with functional magnetic resonance imaging (fMRI) during subjectively calibrated thumbnail pressure pain stimulations at baseline and following intervention. A significant main effect of exercise (post > pre) was observed both in FM patients and HC, in pain-related brain activation within left dorsolateral prefrontal cortex and caudate, as well as increased functional connectivity between caudate and occipital lobe bordering cerebellum (driven by the FM patients). In conclusion, the results indicate that 15-week resistance exercise affect pain-related processing within the cortico-striatal-occipital networks (involved in motor control and cognition), rather than directly influencing top-down descending pain inhibition. In alignment with this, exercise-induced hypoalgesia remained unaltered.http://www.sciencedirect.com/science/article/pii/S2452073X23000016FibromyalgiaExercise interventionExercise induced hypoalgesiaPressure painFunctional magnetic resonance imaging (fMRI)Functional connectivity |
| spellingShingle | Monika Löfgren Angelica Sandström Indre Bileviciute-Ljungar Kaisa Mannerkorpi Björn Gerdle Malin Ernberg Peter Fransson Eva Kosek The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia Neurobiology of Pain Fibromyalgia Exercise intervention Exercise induced hypoalgesia Pressure pain Functional magnetic resonance imaging (fMRI) Functional connectivity |
| title | The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia |
| title_full | The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia |
| title_fullStr | The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia |
| title_full_unstemmed | The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia |
| title_short | The effects of a 15-week physical exercise intervention on pain modulation in fibromyalgia: Increased pain-related processing within the cortico-striatal- occipital networks, but no improvement of exercise-induced hypoalgesia |
| title_sort | effects of a 15 week physical exercise intervention on pain modulation in fibromyalgia increased pain related processing within the cortico striatal occipital networks but no improvement of exercise induced hypoalgesia |
| topic | Fibromyalgia Exercise intervention Exercise induced hypoalgesia Pressure pain Functional magnetic resonance imaging (fMRI) Functional connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S2452073X23000016 |
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