Effect of different exercise intensities on the pancreas of animals with metabolic syndrome
Fernanda Amaral,1 Nathalia EA Lima,1 Elisabete Ornelas,1 Lucila Simardi,2 Fernando Luiz Affonso Fonseca,2,3 Laura Beatriz Mesiano Maifrino1,4 1Laboratório de Estudos Morfoquantitativo e Imunohistoquímico, Universidade São Judas Tadeu, São Paulo, Brazil; 2F...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-02-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Online Access: | http://www.dovepress.com/effect-of-different-exercise-intensities-on-the-pancreas-of-animals-wi-peer-reviewed-article-DMSO |
| _version_ | 1811173804159795200 |
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| author | Amaral F Lima NEA Ornelas E Simardi L Fonseca FLA Maifrino LBM |
| author_facet | Amaral F Lima NEA Ornelas E Simardi L Fonseca FLA Maifrino LBM |
| author_sort | Amaral F |
| collection | DOAJ |
| description | Fernanda Amaral,1 Nathalia EA Lima,1 Elisabete Ornelas,1 Lucila Simardi,2 Fernando Luiz Affonso Fonseca,2,3 Laura Beatriz Mesiano Maifrino1,4 1Laboratório de Estudos Morfoquantitativo e Imunohistoquímico, Universidade São Judas Tadeu, São Paulo, Brazil; 2Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil; 3Departamento de Ciências Biológicas, Universidade Federal de São Paulo, São Paulo, Brazil; 4Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil Introduction: Metabolic syndrome (MS) comprises several metabolic disorders that are risk factors for cardiovascular disease and has its source connected to the accumulation of visceral adipose tissue (VAT) and development of insulin resistance. Despite studies showing beneficial results of exercise on several risk factors for cardiovascular disease, studies evaluating the effects of different intensities of exercise training on the pancreas with experimental models are scarce. Methods: In total, 20 Wistar rats were used, divided into four groups: control (C), metabolic syndrome (MS and without exercise), metabolic syndrome and practice of walking (MSWalk), and metabolic syndrome and practice of running (MSRun). The applied procedures were induction of MS by fructose in drinking water; experimental protocol of walking and running; weighing of body mass and VAT; sacrifice of animals with blood collection and removal of organs and processing of samples for light microscopy using the analysis of volume densities (Vv) of the studied structures. Results: Running showed a reduction of VAT weight (–54%), triglyceride levels (–40%), Vv[islet] (–62%), Vv[islet.cells] (–22%), Vv[islet.insterstitial] (–44%), and Vv[acinar.insterstitial] (–24%) and an increase of Vv[acini] (+21%) and Vv[acinar.cells] (+22%). Regarding walking, we observed a decrease of VAT weight (–34%) and triglyceride levels (–27%), an increase of Vv[islet.cells] (+72%) and Vv[acinar.cells] (+7%), and a decrease of Vv[acini] (–4%) and Vv[acinar.insterstitial] (–16%) when compared with those in the MS group. Conclusion: Our results suggest that the experimental model with low-intensity exercise (walking) seems to be more particularly recommended for preventing morphological and metabolic disorders occurring in the MS. Keywords: metabolic syndrome, pancreas, exercise, visceral adipose tissue, insulin resistance |
| first_indexed | 2024-04-10T17:52:59Z |
| format | Article |
| id | doaj.art-71fcd73b0ee242a9affa4c193e6bd3eb |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T17:52:59Z |
| publishDate | 2015-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-71fcd73b0ee242a9affa4c193e6bd3eb2023-02-02T19:40:32ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072015-02-012015default11512020448Effect of different exercise intensities on the pancreas of animals with metabolic syndromeAmaral FLima NEAOrnelas ESimardi LFonseca FLAMaifrino LBMFernanda Amaral,1 Nathalia EA Lima,1 Elisabete Ornelas,1 Lucila Simardi,2 Fernando Luiz Affonso Fonseca,2,3 Laura Beatriz Mesiano Maifrino1,4 1Laboratório de Estudos Morfoquantitativo e Imunohistoquímico, Universidade São Judas Tadeu, São Paulo, Brazil; 2Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil; 3Departamento de Ciências Biológicas, Universidade Federal de São Paulo, São Paulo, Brazil; 4Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil Introduction: Metabolic syndrome (MS) comprises several metabolic disorders that are risk factors for cardiovascular disease and has its source connected to the accumulation of visceral adipose tissue (VAT) and development of insulin resistance. Despite studies showing beneficial results of exercise on several risk factors for cardiovascular disease, studies evaluating the effects of different intensities of exercise training on the pancreas with experimental models are scarce. Methods: In total, 20 Wistar rats were used, divided into four groups: control (C), metabolic syndrome (MS and without exercise), metabolic syndrome and practice of walking (MSWalk), and metabolic syndrome and practice of running (MSRun). The applied procedures were induction of MS by fructose in drinking water; experimental protocol of walking and running; weighing of body mass and VAT; sacrifice of animals with blood collection and removal of organs and processing of samples for light microscopy using the analysis of volume densities (Vv) of the studied structures. Results: Running showed a reduction of VAT weight (–54%), triglyceride levels (–40%), Vv[islet] (–62%), Vv[islet.cells] (–22%), Vv[islet.insterstitial] (–44%), and Vv[acinar.insterstitial] (–24%) and an increase of Vv[acini] (+21%) and Vv[acinar.cells] (+22%). Regarding walking, we observed a decrease of VAT weight (–34%) and triglyceride levels (–27%), an increase of Vv[islet.cells] (+72%) and Vv[acinar.cells] (+7%), and a decrease of Vv[acini] (–4%) and Vv[acinar.insterstitial] (–16%) when compared with those in the MS group. Conclusion: Our results suggest that the experimental model with low-intensity exercise (walking) seems to be more particularly recommended for preventing morphological and metabolic disorders occurring in the MS. Keywords: metabolic syndrome, pancreas, exercise, visceral adipose tissue, insulin resistance http://www.dovepress.com/effect-of-different-exercise-intensities-on-the-pancreas-of-animals-wi-peer-reviewed-article-DMSO |
| spellingShingle | Amaral F Lima NEA Ornelas E Simardi L Fonseca FLA Maifrino LBM Effect of different exercise intensities on the pancreas of animals with metabolic syndrome Diabetes, Metabolic Syndrome and Obesity |
| title | Effect of different exercise intensities on the pancreas of animals with metabolic syndrome |
| title_full | Effect of different exercise intensities on the pancreas of animals with metabolic syndrome |
| title_fullStr | Effect of different exercise intensities on the pancreas of animals with metabolic syndrome |
| title_full_unstemmed | Effect of different exercise intensities on the pancreas of animals with metabolic syndrome |
| title_short | Effect of different exercise intensities on the pancreas of animals with metabolic syndrome |
| title_sort | effect of different exercise intensities on the pancreas of animals with metabolic syndrome |
| url | http://www.dovepress.com/effect-of-different-exercise-intensities-on-the-pancreas-of-animals-wi-peer-reviewed-article-DMSO |
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