Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study
Background: In the majority of cases, the treatment method for Cleft lip is surgery. Providing adequate pain control during and after surgery for children, is too important. Also, different methods are used for pain relief like analgesic prescription and nerve block and different adjuvants can be a...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2024-01-01
|
| Series: | Archives of Anesthesia and Critical Care |
| Subjects: | |
| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/760 |
| _version_ | 1827291073998749696 |
|---|---|
| author | Sedighe Shahhosseini Mohammad Montasery Iman Raeisi Amir Shafa Mohammad Omid Mehrdad Memarzadeh Yasaman Borghei |
| author_facet | Sedighe Shahhosseini Mohammad Montasery Iman Raeisi Amir Shafa Mohammad Omid Mehrdad Memarzadeh Yasaman Borghei |
| author_sort | Sedighe Shahhosseini |
| collection | DOAJ |
| description |
Background: In the majority of cases, the treatment method for Cleft lip is surgery. Providing adequate pain control during and after surgery for children, is too important. Also, different methods are used for pain relief like analgesic prescription and nerve block and different adjuvants can be added to anesthetics to reduce pain.
Aims: This trial was aimed to compare the analgesic effect of Bupivacaine with or without dexmedetomidine or dexamethasone for cleft lip surgery.
Methods: This study is a prospective, double-blinded, randomized trial which conducted on 75 pediatrics, aged between 3 to 10 months, who needed unilateral cleft lip surgery. Patients were divided into 3 groups (n=25 in each group). Children in group A, were given a combination of bupivacaine and 0.5 µg/kg of dexmedetomidine, those in group B, 0.1 mg/kg of dexamethasone as an adjuvant to bupivacaine, and in group C, plain 1 cc of bupivacaine 0.5% was injected in the operation site. Outcomes were assessed via FLACC and WATCHA scores.
Results: The mean age among children was 4.3 ±1.29 months and mean weight was 6.3± 1.09 kg. Pain score and frequency of analgesic request intra and post-operation in group A was lower than others (p<0.0001). Also, FLACC and WATCHA scores were significantly lower in group A (p<0.0001) and parental and surgeon satisfaction was higher in group A (p<0.05).
Conclusion: Our study showed that, dexmedetomidine as an adjuvant to bupivacaine 0.5% is more effective to improve the analgesia, in children who underwent unilateral cleft lip surgery.
|
| first_indexed | 2024-04-24T12:29:39Z |
| format | Article |
| id | doaj.art-71fdcf5795b84b73b718b5ae230495c6 |
| institution | Directory Open Access Journal |
| issn | 2423-5849 |
| language | English |
| last_indexed | 2024-04-24T12:29:39Z |
| publishDate | 2024-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj.art-71fdcf5795b84b73b718b5ae230495c62024-04-08T06:28:13ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492024-01-0110210.18502/aacc.v10i2.15058Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded StudySedighe Shahhosseini0Mohammad Montasery1Iman Raeisi2Amir Shafa3Mohammad Omid4Mehrdad Memarzadeh5Yasaman Borghei6Department of Anesthesiology, Anesthesiology and Critical Care Research Centre, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Anesthesiology, Anesthesiology and Critical Care Research Centre, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Anesthesiology, Anesthesiology and Critical Care Research Centre, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Anesthesiology, Anesthesiology and Critical Care Research Centre, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Pediatric Surgery, Surgery Research Center, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Pediatric Surgery, Surgery Research Center, Emam hossein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Background: In the majority of cases, the treatment method for Cleft lip is surgery. Providing adequate pain control during and after surgery for children, is too important. Also, different methods are used for pain relief like analgesic prescription and nerve block and different adjuvants can be added to anesthetics to reduce pain. Aims: This trial was aimed to compare the analgesic effect of Bupivacaine with or without dexmedetomidine or dexamethasone for cleft lip surgery. Methods: This study is a prospective, double-blinded, randomized trial which conducted on 75 pediatrics, aged between 3 to 10 months, who needed unilateral cleft lip surgery. Patients were divided into 3 groups (n=25 in each group). Children in group A, were given a combination of bupivacaine and 0.5 µg/kg of dexmedetomidine, those in group B, 0.1 mg/kg of dexamethasone as an adjuvant to bupivacaine, and in group C, plain 1 cc of bupivacaine 0.5% was injected in the operation site. Outcomes were assessed via FLACC and WATCHA scores. Results: The mean age among children was 4.3 ±1.29 months and mean weight was 6.3± 1.09 kg. Pain score and frequency of analgesic request intra and post-operation in group A was lower than others (p<0.0001). Also, FLACC and WATCHA scores were significantly lower in group A (p<0.0001) and parental and surgeon satisfaction was higher in group A (p<0.05). Conclusion: Our study showed that, dexmedetomidine as an adjuvant to bupivacaine 0.5% is more effective to improve the analgesia, in children who underwent unilateral cleft lip surgery. https://aacc.tums.ac.ir/index.php/aacc/article/view/760Cleft lipAnalgesiaAnesthesiaPediatric |
| spellingShingle | Sedighe Shahhosseini Mohammad Montasery Iman Raeisi Amir Shafa Mohammad Omid Mehrdad Memarzadeh Yasaman Borghei Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study Archives of Anesthesia and Critical Care Cleft lip Analgesia Anesthesia Pediatric |
| title | Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study |
| title_full | Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study |
| title_fullStr | Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study |
| title_full_unstemmed | Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study |
| title_short | Analgesic Efficacy of Dexamethasone and Dexmedetomidine as an Adjuvant to Bupivacaine Infiltration in Unilateral Cleft Lip Surgery: A Randomized, Double-Blinded Study |
| title_sort | analgesic efficacy of dexamethasone and dexmedetomidine as an adjuvant to bupivacaine infiltration in unilateral cleft lip surgery a randomized double blinded study |
| topic | Cleft lip Analgesia Anesthesia Pediatric |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/760 |
| work_keys_str_mv | AT sedigheshahhosseini analgesicefficacyofdexamethasoneanddexmedetomidineasanadjuvanttobupivacaineinfiltrationinunilateralcleftlipsurgeryarandomizeddoubleblindedstudy AT mohammadmontasery analgesicefficacyofdexamethasoneanddexmedetomidineasanadjuvanttobupivacaineinfiltrationinunilateralcleftlipsurgeryarandomizeddoubleblindedstudy AT imanraeisi analgesicefficacyofdexamethasoneanddexmedetomidineasanadjuvanttobupivacaineinfiltrationinunilateralcleftlipsurgeryarandomizeddoubleblindedstudy AT amirshafa analgesicefficacyofdexamethasoneanddexmedetomidineasanadjuvanttobupivacaineinfiltrationinunilateralcleftlipsurgeryarandomizeddoubleblindedstudy AT mohammadomid analgesicefficacyofdexamethasoneanddexmedetomidineasanadjuvanttobupivacaineinfiltrationinunilateralcleftlipsurgeryarandomizeddoubleblindedstudy AT mehrdadmemarzadeh analgesicefficacyofdexamethasoneanddexmedetomidineasanadjuvanttobupivacaineinfiltrationinunilateralcleftlipsurgeryarandomizeddoubleblindedstudy AT yasamanborghei analgesicefficacyofdexamethasoneanddexmedetomidineasanadjuvanttobupivacaineinfiltrationinunilateralcleftlipsurgeryarandomizeddoubleblindedstudy |