Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stage
Abstract Objectives This study aimed to assess the epidemiological features and explore the potential risk factors for early neurological deterioration (END) in patients with acute single small subcortical infarction (SSSI) who underwent antiplatelet therapy without carotid artery stenosis. Material...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-023-03128-3 |
| _version_ | 1797864356774412288 |
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| author | Di Jin Jing Yang Hui Zhu Yuexia Wu Haichao Liu Qi Wang Xiaoyun Zhang Yanhua Dong Bin Luo Yong Shan Lvming Zhang Peifu Wang Jichen Du |
| author_facet | Di Jin Jing Yang Hui Zhu Yuexia Wu Haichao Liu Qi Wang Xiaoyun Zhang Yanhua Dong Bin Luo Yong Shan Lvming Zhang Peifu Wang Jichen Du |
| author_sort | Di Jin |
| collection | DOAJ |
| description | Abstract Objectives This study aimed to assess the epidemiological features and explore the potential risk factors for early neurological deterioration (END) in patients with acute single small subcortical infarction (SSSI) who underwent antiplatelet therapy without carotid artery stenosis. Materials & methods Patients with SSSI, as confirmed by cranial magnetic resonance imaging (MRI), who were hospitalized within 48 h after the onset of symptoms were enrolled. END was mainly defined as increment in the National Institutes of Health Stroke Scale (NIHSS) score of ≥ 2 points or any new neurological deficit. Poor functional outcome was defined as modified Rankin Scale (mRS) score of > 2 points at 3-month after the onset. The association of END with multiple indicators was assessed at the early stage of admission using multivariate logistic regression analysis, and adjusted odds ratios (aORs) were calculated. Results A total of 280 patients were enrolled from June 2020 to May 2021, of whom, END occurred in 44 (15.7%) patients (median age, 64 years; 70.5% male), while END occurred during sleep in 28 (63.6%) patients. History of hypertension (aOR: 4.82, p = 0.001), infarction in internal capsule (aOR: 3.35, p = 0.001), and elevated level of low-density lipoprotein cholesterol (LDL-C; aOR: 0.036, p = 0.0016) were significantly associated with the risk of END. Patients with END (aOR: 5.74, p = 0.002), history of diabetes (aOR: 2.61, p = 0.020), and higher NIHSS scores at discharge (per 1-score increase, aOR: 1.29, p = 0.026) were associated with the poor functional outcome at 3-month after the onset. Conclusion Patients with a history of hypertension, infarction in internal capsule or a higher level of LDL-C were found to be at a higher risk of END. |
| first_indexed | 2024-04-09T22:51:42Z |
| format | Article |
| id | doaj.art-720467b27bee471ca121c841843ab1ea |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-09T22:51:42Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-720467b27bee471ca121c841843ab1ea2023-03-22T11:38:00ZengBMCBMC Neurology1471-23772023-02-012311910.1186/s12883-023-03128-3Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stageDi Jin0Jing Yang1Hui Zhu2Yuexia Wu3Haichao Liu4Qi Wang5Xiaoyun Zhang6Yanhua Dong7Bin Luo8Yong Shan9Lvming Zhang10Peifu Wang11Jichen Du12Department of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalGraduate School of the First Hospital of Hebei Medical University, Hebei Medical UniversityDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalAbstract Objectives This study aimed to assess the epidemiological features and explore the potential risk factors for early neurological deterioration (END) in patients with acute single small subcortical infarction (SSSI) who underwent antiplatelet therapy without carotid artery stenosis. Materials & methods Patients with SSSI, as confirmed by cranial magnetic resonance imaging (MRI), who were hospitalized within 48 h after the onset of symptoms were enrolled. END was mainly defined as increment in the National Institutes of Health Stroke Scale (NIHSS) score of ≥ 2 points or any new neurological deficit. Poor functional outcome was defined as modified Rankin Scale (mRS) score of > 2 points at 3-month after the onset. The association of END with multiple indicators was assessed at the early stage of admission using multivariate logistic regression analysis, and adjusted odds ratios (aORs) were calculated. Results A total of 280 patients were enrolled from June 2020 to May 2021, of whom, END occurred in 44 (15.7%) patients (median age, 64 years; 70.5% male), while END occurred during sleep in 28 (63.6%) patients. History of hypertension (aOR: 4.82, p = 0.001), infarction in internal capsule (aOR: 3.35, p = 0.001), and elevated level of low-density lipoprotein cholesterol (LDL-C; aOR: 0.036, p = 0.0016) were significantly associated with the risk of END. Patients with END (aOR: 5.74, p = 0.002), history of diabetes (aOR: 2.61, p = 0.020), and higher NIHSS scores at discharge (per 1-score increase, aOR: 1.29, p = 0.026) were associated with the poor functional outcome at 3-month after the onset. Conclusion Patients with a history of hypertension, infarction in internal capsule or a higher level of LDL-C were found to be at a higher risk of END.https://doi.org/10.1186/s12883-023-03128-3Single small subcortical infarctionStrokeLacunar infarctionEarly neurological deteriorationRisk factor |
| spellingShingle | Di Jin Jing Yang Hui Zhu Yuexia Wu Haichao Liu Qi Wang Xiaoyun Zhang Yanhua Dong Bin Luo Yong Shan Lvming Zhang Peifu Wang Jichen Du Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stage BMC Neurology Single small subcortical infarction Stroke Lacunar infarction Early neurological deterioration Risk factor |
| title | Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stage |
| title_full | Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stage |
| title_fullStr | Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stage |
| title_full_unstemmed | Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stage |
| title_short | Risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis: predictors at the early stage |
| title_sort | risk factors for early neurologic deterioration in single small subcortical infarction without carrier artery stenosis predictors at the early stage |
| topic | Single small subcortical infarction Stroke Lacunar infarction Early neurological deterioration Risk factor |
| url | https://doi.org/10.1186/s12883-023-03128-3 |
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