Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder
Intravesical instillation allows for direct exposure of the urothelium to a drug. However, the therapeutic efficacy is often limited by the rapid elimination of the drug from the bladder. In this investigation, it is hypothesized that the morphology of nanoparticulate drug delivery systems could sig...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2022-05-01
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| Series: | Advanced NanoBiomed Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/anbr.202100138 |
| _version_ | 1818230451332972544 |
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| author | Raul Diaz-Salmeron Balthazar Toussaint Catherine Cailleau Gilles Ponchel Kawthar Bouchemal |
| author_facet | Raul Diaz-Salmeron Balthazar Toussaint Catherine Cailleau Gilles Ponchel Kawthar Bouchemal |
| author_sort | Raul Diaz-Salmeron |
| collection | DOAJ |
| description | Intravesical instillation allows for direct exposure of the urothelium to a drug. However, the therapeutic efficacy is often limited by the rapid elimination of the drug from the bladder. In this investigation, it is hypothesized that the morphology of nanoparticulate drug delivery systems could significantly impact bioadhesion and bioelimination from the bladder. Bioadhesion kinetics evaluated ex vivo on rat bladder mucosa demonstrates that particles with a flattened morphology, denoted as nanoplatelets, are rapidly attached to the mucosa at a lower concentration than nanospheres. The two particles have comparable surface potentials and equivalent volumes and are composed of hyaluronan, a nonsulfated polysaccharide that plays a significant role in restoring the bladder glycosaminoglycan layer. The bioaccumulation and bioelimination studied in vivo reveal that the nanoplatelets are eliminated from the rat bladders less rapidly than nanospheres. This investigation suggests that the bioadhesion of HA could be improved by optimizing particle morphology, opening new opportunities for the treatment of local urothelial diseases, such as interstitial cystitis/painful bladder syndrome, by restoring the loss of the glycosaminoglycan layer. |
| first_indexed | 2024-12-12T10:34:42Z |
| format | Article |
| id | doaj.art-720531a436c544c0ab1f907acca7df58 |
| institution | Directory Open Access Journal |
| issn | 2699-9307 |
| language | English |
| last_indexed | 2024-12-12T10:34:42Z |
| publishDate | 2022-05-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced NanoBiomed Research |
| spelling | doaj.art-720531a436c544c0ab1f907acca7df582022-12-22T00:27:15ZengWiley-VCHAdvanced NanoBiomed Research2699-93072022-05-0125n/an/a10.1002/anbr.202100138Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the BladderRaul Diaz-Salmeron0Balthazar Toussaint1Catherine Cailleau2Gilles Ponchel3Kawthar Bouchemal4Institut Galien Paris Saclay, CNRS UMR 8612 Université Paris-Saclay 92296 Châtenay-Malabry FranceInstitut Galien Paris Saclay, CNRS UMR 8612 Université Paris-Saclay 92296 Châtenay-Malabry FranceInstitut Galien Paris Saclay, CNRS UMR 8612 Université Paris-Saclay 92296 Châtenay-Malabry FranceInstitut Galien Paris Saclay, CNRS UMR 8612 Université Paris-Saclay 92296 Châtenay-Malabry FranceInstitut Galien Paris Saclay, CNRS UMR 8612 Université Paris-Saclay 92296 Châtenay-Malabry FranceIntravesical instillation allows for direct exposure of the urothelium to a drug. However, the therapeutic efficacy is often limited by the rapid elimination of the drug from the bladder. In this investigation, it is hypothesized that the morphology of nanoparticulate drug delivery systems could significantly impact bioadhesion and bioelimination from the bladder. Bioadhesion kinetics evaluated ex vivo on rat bladder mucosa demonstrates that particles with a flattened morphology, denoted as nanoplatelets, are rapidly attached to the mucosa at a lower concentration than nanospheres. The two particles have comparable surface potentials and equivalent volumes and are composed of hyaluronan, a nonsulfated polysaccharide that plays a significant role in restoring the bladder glycosaminoglycan layer. The bioaccumulation and bioelimination studied in vivo reveal that the nanoplatelets are eliminated from the rat bladders less rapidly than nanospheres. This investigation suggests that the bioadhesion of HA could be improved by optimizing particle morphology, opening new opportunities for the treatment of local urothelial diseases, such as interstitial cystitis/painful bladder syndrome, by restoring the loss of the glycosaminoglycan layer.https://doi.org/10.1002/anbr.202100138bladderbioadhesionbioeliminationglycosaminoglycanshyaluronannanoparticles |
| spellingShingle | Raul Diaz-Salmeron Balthazar Toussaint Catherine Cailleau Gilles Ponchel Kawthar Bouchemal Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder Advanced NanoBiomed Research bladder bioadhesion bioelimination glycosaminoglycans hyaluronan nanoparticles |
| title | Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder |
| title_full | Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder |
| title_fullStr | Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder |
| title_full_unstemmed | Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder |
| title_short | Morphology‐Dependent Bioadhesion and Bioelimination of Hyaluronan Particles Administered in the Bladder |
| title_sort | morphology dependent bioadhesion and bioelimination of hyaluronan particles administered in the bladder |
| topic | bladder bioadhesion bioelimination glycosaminoglycans hyaluronan nanoparticles |
| url | https://doi.org/10.1002/anbr.202100138 |
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