The Potential Adjuvanticity of CAvant<sup>®</sup>SOE for Foot-and-Mouth Disease Vaccine
Foot-and-mouth disease (FMD) is a notifiable contagious disease of cloven-hoofed mammals. A high potency vaccine that stimulates the host immune response is the foremost strategy used to prevent disease persistence in endemic regions. FMD vaccines comprise inactivated virus antigens whose immunogeni...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/10/1091 |
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| author | Young-Hoon Ahn W. A. Gayan Chathuranga Young-Jung Shim D. K. Haluwana Eun-Hee Kim In-Joong Yoon Yong-Taik Lim Sung Ho Shin Hyundong Jo Seong Yun Hwang Hyun Mi Kim Min Ja Lee Jong-Hyeon Park Sung-Sik Yoo Jong-Soo Lee |
| author_facet | Young-Hoon Ahn W. A. Gayan Chathuranga Young-Jung Shim D. K. Haluwana Eun-Hee Kim In-Joong Yoon Yong-Taik Lim Sung Ho Shin Hyundong Jo Seong Yun Hwang Hyun Mi Kim Min Ja Lee Jong-Hyeon Park Sung-Sik Yoo Jong-Soo Lee |
| author_sort | Young-Hoon Ahn |
| collection | DOAJ |
| description | Foot-and-mouth disease (FMD) is a notifiable contagious disease of cloven-hoofed mammals. A high potency vaccine that stimulates the host immune response is the foremost strategy used to prevent disease persistence in endemic regions. FMD vaccines comprise inactivated virus antigens whose immunogenicity is potentiated by immunogenic adjuvants. Oil-based adjuvants have clear advantages over traditional adjuvant vaccines; however, there is potential to develop novel adjuvants to increase the potency of FMD vaccines. Thus, we aimed to evaluate the efficacy of a novel water-in-oil emulsion, called CAvant<sup>®</sup>SOE, as a novel vaccine adjuvant for use with inactivated FMD vaccines. In this study, we found that inactivated A22 Iraq virus plus CAvant<sup>®</sup>SOE (iA22 Iraq-CAvant<sup>®</sup>SOE) induced effective antigen-specific humoral (IgG, IgG1, and IgG2a) and cell-mediated immune responses (IFN-γ and IL-4) in mice. Immunization of pigs with a single dose of iA22 Iraq-CAvant<sup>®</sup>SOE also elicited effective protection, with no detectable clinical symptoms against challenge with heterologous A/SKR/GP/2018 FMDV. Levels of protection are strongly in line with vaccine-induced neutralizing antibody titers. Collectively, these results indicate that CAvant<sup>®</sup>SOE-adjuvanted vaccine is a promising candidate for control of FMD in pigs. |
| first_indexed | 2024-03-10T06:09:29Z |
| format | Article |
| id | doaj.art-720630c7e18348cb919804615fac80b6 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T06:09:29Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-720630c7e18348cb919804615fac80b62023-11-22T20:14:59ZengMDPI AGVaccines2076-393X2021-09-01910109110.3390/vaccines9101091The Potential Adjuvanticity of CAvant<sup>®</sup>SOE for Foot-and-Mouth Disease VaccineYoung-Hoon Ahn0W. A. Gayan Chathuranga1Young-Jung Shim2D. K. Haluwana3Eun-Hee Kim4In-Joong Yoon5Yong-Taik Lim6Sung Ho Shin7Hyundong Jo8Seong Yun Hwang9Hyun Mi Kim10Min Ja Lee11Jong-Hyeon Park12Sung-Sik Yoo13Jong-Soo Lee14Choong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, KoreaCollege of Veterinary Medicine, Chungnam National University, Daejeon 34314, KoreaChoong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, KoreaCollege of Veterinary Medicine, Chungnam National University, Daejeon 34314, KoreaChoong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, KoreaChoong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, KoreaDepartment of Nano Engineering, Sungkyunkwan University, Suwon 16419, KoreaAnimal and Plant Quarantine Agency, Gimcheon 39660, KoreaAnimal and Plant Quarantine Agency, Gimcheon 39660, KoreaAnimal and Plant Quarantine Agency, Gimcheon 39660, KoreaAnimal and Plant Quarantine Agency, Gimcheon 39660, KoreaAnimal and Plant Quarantine Agency, Gimcheon 39660, KoreaAnimal and Plant Quarantine Agency, Gimcheon 39660, KoreaChoong Ang Vaccine Laboratory Co., Ltd., Daejeon 34055, KoreaCollege of Veterinary Medicine, Chungnam National University, Daejeon 34314, KoreaFoot-and-mouth disease (FMD) is a notifiable contagious disease of cloven-hoofed mammals. A high potency vaccine that stimulates the host immune response is the foremost strategy used to prevent disease persistence in endemic regions. FMD vaccines comprise inactivated virus antigens whose immunogenicity is potentiated by immunogenic adjuvants. Oil-based adjuvants have clear advantages over traditional adjuvant vaccines; however, there is potential to develop novel adjuvants to increase the potency of FMD vaccines. Thus, we aimed to evaluate the efficacy of a novel water-in-oil emulsion, called CAvant<sup>®</sup>SOE, as a novel vaccine adjuvant for use with inactivated FMD vaccines. In this study, we found that inactivated A22 Iraq virus plus CAvant<sup>®</sup>SOE (iA22 Iraq-CAvant<sup>®</sup>SOE) induced effective antigen-specific humoral (IgG, IgG1, and IgG2a) and cell-mediated immune responses (IFN-γ and IL-4) in mice. Immunization of pigs with a single dose of iA22 Iraq-CAvant<sup>®</sup>SOE also elicited effective protection, with no detectable clinical symptoms against challenge with heterologous A/SKR/GP/2018 FMDV. Levels of protection are strongly in line with vaccine-induced neutralizing antibody titers. Collectively, these results indicate that CAvant<sup>®</sup>SOE-adjuvanted vaccine is a promising candidate for control of FMD in pigs.https://www.mdpi.com/2076-393X/9/10/1091foot-and-mouth disease virusvaccineadjuvantwater-in-oil emulsionCAvant<sup>®</sup>SOE |
| spellingShingle | Young-Hoon Ahn W. A. Gayan Chathuranga Young-Jung Shim D. K. Haluwana Eun-Hee Kim In-Joong Yoon Yong-Taik Lim Sung Ho Shin Hyundong Jo Seong Yun Hwang Hyun Mi Kim Min Ja Lee Jong-Hyeon Park Sung-Sik Yoo Jong-Soo Lee The Potential Adjuvanticity of CAvant<sup>®</sup>SOE for Foot-and-Mouth Disease Vaccine Vaccines foot-and-mouth disease virus vaccine adjuvant water-in-oil emulsion CAvant<sup>®</sup>SOE |
| title | The Potential Adjuvanticity of CAvant<sup>®</sup>SOE for Foot-and-Mouth Disease Vaccine |
| title_full | The Potential Adjuvanticity of CAvant<sup>®</sup>SOE for Foot-and-Mouth Disease Vaccine |
| title_fullStr | The Potential Adjuvanticity of CAvant<sup>®</sup>SOE for Foot-and-Mouth Disease Vaccine |
| title_full_unstemmed | The Potential Adjuvanticity of CAvant<sup>®</sup>SOE for Foot-and-Mouth Disease Vaccine |
| title_short | The Potential Adjuvanticity of CAvant<sup>®</sup>SOE for Foot-and-Mouth Disease Vaccine |
| title_sort | potential adjuvanticity of cavant sup r sup soe for foot and mouth disease vaccine |
| topic | foot-and-mouth disease virus vaccine adjuvant water-in-oil emulsion CAvant<sup>®</sup>SOE |
| url | https://www.mdpi.com/2076-393X/9/10/1091 |
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