Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients

Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients

HLA-DRB1 alleles have been associated with several autoimmune diseases. For anti-citrullinated protein antibody positive rheumatoid arthritis (RA), HLA-DRB1 shared epitope (SE) alleles are the major genetic risk factors. In order to study the genetic regulation of major histocompatibility complex (M...

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Bibliographic Details
Main Authors: Miranda Houtman, Espen Hesselberg, Lars Rönnblom, Lars Klareskog, Vivianne Malmström, Leonid Padyukov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
major histocompatibility complex
RNA-sequencing
allelic expression
T cell
monocyte
rheumatoid arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.707217/full

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