Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy
Abstract Oral administration is preferred over other drug delivery methods due to its safety, high patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of medications. However, oral drug delivery is limited by the poor oral bioavailability of many drugs, caused by...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-01991-3 |
| _version_ | 1797556721939382272 |
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| author | Yang-Bao Miao Tianxing Xu Ying Gong Anmei Chen Liang Zou Tao Jiang Yi Shi |
| author_facet | Yang-Bao Miao Tianxing Xu Ying Gong Anmei Chen Liang Zou Tao Jiang Yi Shi |
| author_sort | Yang-Bao Miao |
| collection | DOAJ |
| description | Abstract Oral administration is preferred over other drug delivery methods due to its safety, high patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of medications. However, oral drug delivery is limited by the poor oral bioavailability of many drugs, caused by extreme conditions and absorption challenges in the gastrointestinal tract. This review thoroughly discusses the targeted drug vehicles to the intestinal lymphatic system (ILS). It explores the structure and physiological barriers of the ILS, highlighting its significance in dietary lipid and medication absorption and transport. The review presents various approaches to targeting the ILS using spatially precise vehicles, aiming to enhance bioavailability, achieve targeted delivery, and reduce first-pass metabolism with serve in clinic. Furthermore, the review outlines several methods for leveraging these vehicles to open the ILS window, paving the way for potential clinical applications in cancer treatment and oral vaccine delivery. By focusing on targeted drug vehicles to the ILS, this article emphasizes the critical role of these strategies in improving therapeutic efficacy and patient outcomes. Overall, this article emphasizes the critical role of targeted drug vehicles to the ILS and the potential impact of these strategies on improving therapeutic efficacy and patient outcomes. |
| first_indexed | 2024-03-10T17:05:57Z |
| format | Article |
| id | doaj.art-7209c22235b047249c3daabae612bc02 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-10T17:05:57Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-7209c22235b047249c3daabae612bc022023-11-20T10:48:17ZengBMCJournal of Nanobiotechnology1477-31552023-08-0121112510.1186/s12951-023-01991-3Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapyYang-Bao Miao0Tianxing Xu1Ying Gong2Anmei Chen3Liang Zou4Tao Jiang5Yi Shi6Department of Haematology, School of Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaDepartment of Haematology, School of Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaSchool of Life Science and Engineering, Southwest Jiaotong UniversitySchool of Life Science and Engineering, Southwest Jiaotong UniversitySchool of Food and Biological Engineering, Chengdu UniversityDepartment of Haematology, School of Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaSichuan Provincial Key Laboratory for Human Disease Gene Study, Center for Medical Genetics, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaAbstract Oral administration is preferred over other drug delivery methods due to its safety, high patient compliance, ease of ingestion without discomfort, and tolerance of a wide range of medications. However, oral drug delivery is limited by the poor oral bioavailability of many drugs, caused by extreme conditions and absorption challenges in the gastrointestinal tract. This review thoroughly discusses the targeted drug vehicles to the intestinal lymphatic system (ILS). It explores the structure and physiological barriers of the ILS, highlighting its significance in dietary lipid and medication absorption and transport. The review presents various approaches to targeting the ILS using spatially precise vehicles, aiming to enhance bioavailability, achieve targeted delivery, and reduce first-pass metabolism with serve in clinic. Furthermore, the review outlines several methods for leveraging these vehicles to open the ILS window, paving the way for potential clinical applications in cancer treatment and oral vaccine delivery. By focusing on targeted drug vehicles to the ILS, this article emphasizes the critical role of these strategies in improving therapeutic efficacy and patient outcomes. Overall, this article emphasizes the critical role of targeted drug vehicles to the ILS and the potential impact of these strategies on improving therapeutic efficacy and patient outcomes.https://doi.org/10.1186/s12951-023-01991-3Intestinal lymphatic systemNanoparticleOral deliveryDrug deliveryImmune System |
| spellingShingle | Yang-Bao Miao Tianxing Xu Ying Gong Anmei Chen Liang Zou Tao Jiang Yi Shi Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy Journal of Nanobiotechnology Intestinal lymphatic system Nanoparticle Oral delivery Drug delivery Immune System |
| title | Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy |
| title_full | Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy |
| title_fullStr | Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy |
| title_full_unstemmed | Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy |
| title_short | Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy |
| title_sort | cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy |
| topic | Intestinal lymphatic system Nanoparticle Oral delivery Drug delivery Immune System |
| url | https://doi.org/10.1186/s12951-023-01991-3 |
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