Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics.
Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested that several neonicotinoids cause neurodevelopmental toxicity in mammals. The aim was to establish the...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4701477?pdf=render |
| _version_ | 1818570360798314496 |
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| author | Kouji H Harada Keiko Tanaka Hiroko Sakamoto Mie Imanaka Tamon Niisoe Toshiaki Hitomi Hatasu Kobayashi Hiroko Okuda Sumiko Inoue Koichi Kusakawa Masayo Oshima Kiyohiko Watanabe Makoto Yasojima Takumi Takasuga Akio Koizumi |
| author_facet | Kouji H Harada Keiko Tanaka Hiroko Sakamoto Mie Imanaka Tamon Niisoe Toshiaki Hitomi Hatasu Kobayashi Hiroko Okuda Sumiko Inoue Koichi Kusakawa Masayo Oshima Kiyohiko Watanabe Makoto Yasojima Takumi Takasuga Akio Koizumi |
| author_sort | Kouji H Harada |
| collection | DOAJ |
| description | Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested that several neonicotinoids cause neurodevelopmental toxicity in mammals. The aim was to establish the relationship between oral intake and urinary excretion of neonicotinoids by humans to facilitate biological monitoring, and to estimate dietary neonicotinoid intakes by Japanese adults.Deuterium-labeled neonicotinoid (acetamiprid, clothianidin, dinotefuran, and imidacloprid) microdoses were orally ingested by nine healthy adults, and 24 h pooled urine samples were collected for 4 consecutive days after dosing. The excretion kinetics were modeled using one- and two-compartment models, then validated in a non-deuterium-labeled neonicotinoid microdose study involving 12 healthy adults. Increased urinary concentrations of labeled neonicotinoids were observed after dosing. Clothianidin was recovered unchanged within 3 days, and most dinotefuran was recovered unchanged within 1 day. Around 10% of the imidacloprid dose was excreted unchanged. Most of the acetamiprid was metabolized to desmethyl-acetamiprid. Spot urine samples from 373 Japanese adults were analyzed for neonicotinoids, and daily intakes were estimated. The estimated average daily intake of these neonicotinoids was 0.53-3.66 μg/day. The highest intake of any of the neonicotinoids in the study population was 64.5 μg/day for dinotefuran, and this was <1% of the acceptable daily intake. |
| first_indexed | 2024-12-14T13:40:19Z |
| format | Article |
| id | doaj.art-720acb7ad7c04aad8ffa17eb4026c951 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T13:40:19Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-720acb7ad7c04aad8ffa17eb4026c9512022-12-21T22:59:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014633510.1371/journal.pone.0146335Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics.Kouji H HaradaKeiko TanakaHiroko SakamotoMie ImanakaTamon NiisoeToshiaki HitomiHatasu KobayashiHiroko OkudaSumiko InoueKoichi KusakawaMasayo OshimaKiyohiko WatanabeMakoto YasojimaTakumi TakasugaAkio KoizumiNeonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested that several neonicotinoids cause neurodevelopmental toxicity in mammals. The aim was to establish the relationship between oral intake and urinary excretion of neonicotinoids by humans to facilitate biological monitoring, and to estimate dietary neonicotinoid intakes by Japanese adults.Deuterium-labeled neonicotinoid (acetamiprid, clothianidin, dinotefuran, and imidacloprid) microdoses were orally ingested by nine healthy adults, and 24 h pooled urine samples were collected for 4 consecutive days after dosing. The excretion kinetics were modeled using one- and two-compartment models, then validated in a non-deuterium-labeled neonicotinoid microdose study involving 12 healthy adults. Increased urinary concentrations of labeled neonicotinoids were observed after dosing. Clothianidin was recovered unchanged within 3 days, and most dinotefuran was recovered unchanged within 1 day. Around 10% of the imidacloprid dose was excreted unchanged. Most of the acetamiprid was metabolized to desmethyl-acetamiprid. Spot urine samples from 373 Japanese adults were analyzed for neonicotinoids, and daily intakes were estimated. The estimated average daily intake of these neonicotinoids was 0.53-3.66 μg/day. The highest intake of any of the neonicotinoids in the study population was 64.5 μg/day for dinotefuran, and this was <1% of the acceptable daily intake.http://europepmc.org/articles/PMC4701477?pdf=render |
| spellingShingle | Kouji H Harada Keiko Tanaka Hiroko Sakamoto Mie Imanaka Tamon Niisoe Toshiaki Hitomi Hatasu Kobayashi Hiroko Okuda Sumiko Inoue Koichi Kusakawa Masayo Oshima Kiyohiko Watanabe Makoto Yasojima Takumi Takasuga Akio Koizumi Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics. PLoS ONE |
| title | Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics. |
| title_full | Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics. |
| title_fullStr | Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics. |
| title_full_unstemmed | Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics. |
| title_short | Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics. |
| title_sort | biological monitoring of human exposure to neonicotinoids using urine samples and neonicotinoid excretion kinetics |
| url | http://europepmc.org/articles/PMC4701477?pdf=render |
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