Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet

Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet

Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of lipid droplets in hepatocytes. NAFLD development and progression is associated with an increase in hepatic cholesterol levels and decreased autophagy and lipophagy flux. Previous studies have shown that the expression o...

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Bibliographic Details
Main Authors: Michael W. Lopresti, Wenqi Cui, Breann E. Abernathy, Gavin Fredrickson, Fanta Barrow, Arnav S. Desai, Xavier S. Revelo, Douglas G. Mashek
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
cholesterol/cell and tissue
dietary fat
inflammation
lipase/hepatic
liver
NAFLD
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227521001152

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