Genotoxic Effects of Cylindrospermopsin, Microcystin-LR and Their Binary Mixture in Human Hepatocellular Carcinoma (HepG2) Cell Line

Genotoxic Effects of Cylindrospermopsin, Microcystin-LR and Their Binary Mixture in Human Hepatocellular Carcinoma (HepG2) Cell Line

Simultaneous occurrence of cylindrospermopsin (CYN) and microcystin-LR (MCLR) has been reported in the aquatic environment and thus human exposure to such mixtures is possible. As data on the combined effects of CYN/MCLR are scarce, we aimed to investigate the adverse effects related to genotoxic ac...

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Bibliographic Details
Main Authors: Leticia Díez-Quijada, Klara Hercog, Martina Štampar, Metka Filipič, Ana M. Cameán, Ángeles Jos, Bojana Žegura
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Toxins
Subjects:
DNA double-strand breaks
cell-cycle
mRNA expression
microcystin-LR
cylindrospermopsin
mixture
Online Access:https://www.mdpi.com/2072-6651/12/12/778

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