Corticosteroid-responsive Epilepsia Partialis Continua
Epilepsia partialis continua (EPC) is a rare form of status epilepticus and often refractory to antiepileptic drugs (AEDs). Persistent seizure activity may increase pro-inflammatory biomarkers locally, which may respond to adjunctive corticosteroid treatment, especially in central nervous system (CN...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-03-01
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| Series: | Türk Nöroloji Dergisi |
| Subjects: | |
| Online Access: | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-80090&look4= |
| _version_ | 1797920070645579776 |
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| author | Jayantee Kalita Prakash Chandra Pandey Sarvesh Kumar Chaudhary Varun Kumar Singh Usha Kant Misra |
| author_facet | Jayantee Kalita Prakash Chandra Pandey Sarvesh Kumar Chaudhary Varun Kumar Singh Usha Kant Misra |
| author_sort | Jayantee Kalita |
| collection | DOAJ |
| description | Epilepsia partialis continua (EPC) is a rare form of status epilepticus and often refractory to antiepileptic drugs (AEDs). Persistent seizure activity may increase pro-inflammatory biomarkers locally, which may respond to adjunctive corticosteroid treatment, especially in central nervous system (CNS) infections. We report four children with refractory EPC and the effect of adjunctive corticosteroid in controlling EPC. The duration of EPC ranged between 3 days and 7 months. One patient had secondary generalized convulsive status epilepticus. Cranial computed tomography/magnetic resonance imaging was abnormal in three out of four patients; revealing old infarction in one, tuberculoma in one, and neurocysticercosis in one. Electroencephalography revealed spike and sharp wave discharges on the corresponding cerebral hemisphere. The EPC was refractory to 2-6 AEDs. Following corticosteroid treatment, EPC remitted in two patients with CNS infection, and those with infarction and cryptogenic EPC converted to discrete seizures. In AED-resistant EPC, a short course of corticosteroid may be helpful. |
| first_indexed | 2024-04-10T13:55:21Z |
| format | Article |
| id | doaj.art-720c6f522e524030baea04fbc884aa3c |
| institution | Directory Open Access Journal |
| issn | 1309-2545 |
| language | English |
| last_indexed | 2024-04-10T13:55:21Z |
| publishDate | 2021-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Nöroloji Dergisi |
| spelling | doaj.art-720c6f522e524030baea04fbc884aa3c2023-02-15T16:10:29ZengGalenos YayineviTürk Nöroloji Dergisi1309-25452021-03-01271757810.4274/tnd.2020.80090Corticosteroid-responsive Epilepsia Partialis ContinuaJayantee Kalita0https://orcid.org/0000-0002-6141-3592Prakash Chandra Pandey1https://orcid.org/0000-0001-6747-6212Sarvesh Kumar Chaudhary2https://orcid.org/0000-0002-9829-9113Varun Kumar Singh3https://orcid.org/0000-0003-4589-0273Usha Kant Misra4https://orcid.org/0000-0002-7317-957XSanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Neurology, Uttar Pradesh, IndiaSanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Neurology, Uttar Pradesh, IndiaSanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Neurology, Uttar Pradesh, IndiaInstitute of Medical Sciences, Banaras Hindu University, Department of Neurology, Uttar Pradesh, IndiaSanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Neurology, Uttar Pradesh, IndiaEpilepsia partialis continua (EPC) is a rare form of status epilepticus and often refractory to antiepileptic drugs (AEDs). Persistent seizure activity may increase pro-inflammatory biomarkers locally, which may respond to adjunctive corticosteroid treatment, especially in central nervous system (CNS) infections. We report four children with refractory EPC and the effect of adjunctive corticosteroid in controlling EPC. The duration of EPC ranged between 3 days and 7 months. One patient had secondary generalized convulsive status epilepticus. Cranial computed tomography/magnetic resonance imaging was abnormal in three out of four patients; revealing old infarction in one, tuberculoma in one, and neurocysticercosis in one. Electroencephalography revealed spike and sharp wave discharges on the corresponding cerebral hemisphere. The EPC was refractory to 2-6 AEDs. Following corticosteroid treatment, EPC remitted in two patients with CNS infection, and those with infarction and cryptogenic EPC converted to discrete seizures. In AED-resistant EPC, a short course of corticosteroid may be helpful.https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-80090&look4=epilepsiya parsiyalis kontinuarefrakter epilepsikortikosteroidmrgeeg |
| spellingShingle | Jayantee Kalita Prakash Chandra Pandey Sarvesh Kumar Chaudhary Varun Kumar Singh Usha Kant Misra Corticosteroid-responsive Epilepsia Partialis Continua Türk Nöroloji Dergisi epilepsiya parsiyalis kontinua refrakter epilepsi kortikosteroid mrg eeg |
| title | Corticosteroid-responsive Epilepsia Partialis Continua |
| title_full | Corticosteroid-responsive Epilepsia Partialis Continua |
| title_fullStr | Corticosteroid-responsive Epilepsia Partialis Continua |
| title_full_unstemmed | Corticosteroid-responsive Epilepsia Partialis Continua |
| title_short | Corticosteroid-responsive Epilepsia Partialis Continua |
| title_sort | corticosteroid responsive epilepsia partialis continua |
| topic | epilepsiya parsiyalis kontinua refrakter epilepsi kortikosteroid mrg eeg |
| url | https://tjn.org.tr/jvi.aspx?pdir=tjn&plng=eng&un=TJN-80090&look4= |
| work_keys_str_mv | AT jayanteekalita corticosteroidresponsiveepilepsiapartialiscontinua AT prakashchandrapandey corticosteroidresponsiveepilepsiapartialiscontinua AT sarveshkumarchaudhary corticosteroidresponsiveepilepsiapartialiscontinua AT varunkumarsingh corticosteroidresponsiveepilepsiapartialiscontinua AT ushakantmisra corticosteroidresponsiveepilepsiapartialiscontinua |