Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer
PURPOSE: This paper describes the ability of miRNA value predict oncological outcomes in CRC patients and correlates to clinical and pathologic variables. METHODS: We prospectively analyzed the serological expression of microRNA-21, microRNA-34a, and microRNA-126 in 37 stage II - IV CRC patients a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2016-01-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001300013&tlng=en |
| _version_ | 1818906996085096448 |
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| author | Ana Luiza Normanha Ribeiro de Almeida Mário Vinícius Angelete Alvarez Bernardes Marley Ribeiro Feitosa Fernanda Maris Peria Daniela Pretti da Cunha Tirapelli José Joaquim Ribeiro da Rocha Omar Feres |
| author_facet | Ana Luiza Normanha Ribeiro de Almeida Mário Vinícius Angelete Alvarez Bernardes Marley Ribeiro Feitosa Fernanda Maris Peria Daniela Pretti da Cunha Tirapelli José Joaquim Ribeiro da Rocha Omar Feres |
| author_sort | Ana Luiza Normanha Ribeiro de Almeida |
| collection | DOAJ |
| description | PURPOSE: This paper describes the ability of miRNA value predict oncological outcomes in CRC patients and correlates to clinical and pathologic variables. METHODS: We prospectively analyzed the serological expression of microRNA-21, microRNA-34a, and microRNA-126 in 37 stage II - IV CRC patients and correlate to seven fit counterparts. Serological microRNAs were extracted using the miRNeasy Mini Kit(r) (Qiagen, Hilden, Germany). Quantification of microRNAs was performed using TaqMan Master Mix(r) reagent (Applied Biosystems, USA). RESULTS: We obtained serological underexpression microRNA-21, microRNA-34a, and microRNA-126 in CRC group. However, miRNAs serological values do not impact prognosis. Furthermore, miRNAs was not influenced by CEA values, TNM staging, and histological subtype. CONCLUSION: Despite lower expression of miR-21, miR-34a and miR-126 in the CRC group, no association with poor prognosis was found. |
| first_indexed | 2024-12-19T21:48:06Z |
| format | Article |
| id | doaj.art-720fa183496b40919f3dc5ac84373770 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-19T21:48:06Z |
| publishDate | 2016-01-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-720fa183496b40919f3dc5ac843737702022-12-21T20:04:29ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502016-01-0131suppl 1131810.1590/S0102-86502016001300004Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancerAna Luiza Normanha Ribeiro de AlmeidaMário Vinícius Angelete Alvarez BernardesMarley Ribeiro FeitosaFernanda Maris PeriaDaniela Pretti da Cunha TirapelliJosé Joaquim Ribeiro da RochaOmar FeresPURPOSE: This paper describes the ability of miRNA value predict oncological outcomes in CRC patients and correlates to clinical and pathologic variables. METHODS: We prospectively analyzed the serological expression of microRNA-21, microRNA-34a, and microRNA-126 in 37 stage II - IV CRC patients and correlate to seven fit counterparts. Serological microRNAs were extracted using the miRNeasy Mini Kit(r) (Qiagen, Hilden, Germany). Quantification of microRNAs was performed using TaqMan Master Mix(r) reagent (Applied Biosystems, USA). RESULTS: We obtained serological underexpression microRNA-21, microRNA-34a, and microRNA-126 in CRC group. However, miRNAs serological values do not impact prognosis. Furthermore, miRNAs was not influenced by CEA values, TNM staging, and histological subtype. CONCLUSION: Despite lower expression of miR-21, miR-34a and miR-126 in the CRC group, no association with poor prognosis was found.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001300013&tlng=enColonic Neoplasms. ColonDrug TherapyMicroRNAsSerum |
| spellingShingle | Ana Luiza Normanha Ribeiro de Almeida Mário Vinícius Angelete Alvarez Bernardes Marley Ribeiro Feitosa Fernanda Maris Peria Daniela Pretti da Cunha Tirapelli José Joaquim Ribeiro da Rocha Omar Feres Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer Acta Cirúrgica Brasileira Colonic Neoplasms. Colon Drug Therapy MicroRNAs Serum |
| title | Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer |
| title_full | Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer |
| title_fullStr | Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer |
| title_full_unstemmed | Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer |
| title_short | Serological under expression of microRNA-21, microRNA-34a and microRNA-126 in colorectal cancer |
| title_sort | serological under expression of microrna 21 microrna 34a and microrna 126 in colorectal cancer |
| topic | Colonic Neoplasms. Colon Drug Therapy MicroRNAs Serum |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502016001300013&tlng=en |
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