Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme
Cancer and Parkinson's disease (PD) define two disease entities that include opposite concepts. Indeed, the involved mechanisms are at different ends of a spectrum related to cell survival - one due to enhanced cellular proliferation and the other due to premature cell death. There is increasin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00898/full |
| _version_ | 1819143863448633344 |
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| author | Pauline Mencke Zoé Hanss Ibrahim Boussaad Pierre-Emmanuel Sugier Alexis Elbaz Rejko Krüger Rejko Krüger Rejko Krüger |
| author_facet | Pauline Mencke Zoé Hanss Ibrahim Boussaad Pierre-Emmanuel Sugier Alexis Elbaz Rejko Krüger Rejko Krüger Rejko Krüger |
| author_sort | Pauline Mencke |
| collection | DOAJ |
| description | Cancer and Parkinson's disease (PD) define two disease entities that include opposite concepts. Indeed, the involved mechanisms are at different ends of a spectrum related to cell survival - one due to enhanced cellular proliferation and the other due to premature cell death. There is increasing evidence indicating that patients with neurodegenerative diseases like PD have a reduced incidence for most cancers. In support, epidemiological studies demonstrate an inverse association between PD and cancer. Both conditions apparently can involve the same set of genes, however, in affected tissues the expression was inversely regulated: genes that are down-regulated in PD were found to be up-regulated in cancer and vice versa, for example p53 or PARK7. When comparing glioblastoma multiforme (GBM), a malignant brain tumor with poor overall survival, with PD, astrocytes are dysregulated in both diseases in opposite ways. In addition, common genes, that are involved in both diseases and share common key pathways of cell proliferation and metabolism, were shown to be oppositely deregulated in PD and GBM. Here, we provide an overview of the involvement of PD- and GBM-associated genes in common pathways that are dysregulated in both conditions. Moreover, we illustrate why the simultaneous study of PD and GBM regarding the role of common pathways may lead to a deeper understanding of these still incurable conditions. Eventually, considering the inverse regulation of certain genes in PD and GBM will help to understand their mechanistic basis, and thus to define novel target-based strategies for causative treatments. |
| first_indexed | 2024-12-22T12:33:00Z |
| format | Article |
| id | doaj.art-72112d7c209c4b9aa9d6464b15acad80 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-22T12:33:00Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-72112d7c209c4b9aa9d6464b15acad802022-12-21T18:25:36ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-08-011110.3389/fneur.2020.00898536670Bidirectional Relation Between Parkinson's Disease and Glioblastoma MultiformePauline Mencke0Zoé Hanss1Ibrahim Boussaad2Pierre-Emmanuel Sugier3Alexis Elbaz4Rejko Krüger5Rejko Krüger6Rejko Krüger7Translational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, LuxembourgTranslational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, LuxembourgTranslational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, LuxembourgInstitut de Statistique de l'Université de Paris, Paris, FranceInstitut de Statistique de l'Université de Paris, Paris, FranceTranslational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, LuxembourgParkinson Research Clinic, Centre Hospitalier de Luxembourg (CHL), Luxembourg, LuxembourgTransversal Translational Medicine, Luxembourg Institute of Health (LIH), Luxembourg, LuxembourgCancer and Parkinson's disease (PD) define two disease entities that include opposite concepts. Indeed, the involved mechanisms are at different ends of a spectrum related to cell survival - one due to enhanced cellular proliferation and the other due to premature cell death. There is increasing evidence indicating that patients with neurodegenerative diseases like PD have a reduced incidence for most cancers. In support, epidemiological studies demonstrate an inverse association between PD and cancer. Both conditions apparently can involve the same set of genes, however, in affected tissues the expression was inversely regulated: genes that are down-regulated in PD were found to be up-regulated in cancer and vice versa, for example p53 or PARK7. When comparing glioblastoma multiforme (GBM), a malignant brain tumor with poor overall survival, with PD, astrocytes are dysregulated in both diseases in opposite ways. In addition, common genes, that are involved in both diseases and share common key pathways of cell proliferation and metabolism, were shown to be oppositely deregulated in PD and GBM. Here, we provide an overview of the involvement of PD- and GBM-associated genes in common pathways that are dysregulated in both conditions. Moreover, we illustrate why the simultaneous study of PD and GBM regarding the role of common pathways may lead to a deeper understanding of these still incurable conditions. Eventually, considering the inverse regulation of certain genes in PD and GBM will help to understand their mechanistic basis, and thus to define novel target-based strategies for causative treatments.https://www.frontiersin.org/article/10.3389/fneur.2020.00898/fullParkinson's diseaseglioblastoma multiformepleiotropycancerneurodegeneration |
| spellingShingle | Pauline Mencke Zoé Hanss Ibrahim Boussaad Pierre-Emmanuel Sugier Alexis Elbaz Rejko Krüger Rejko Krüger Rejko Krüger Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme Frontiers in Neurology Parkinson's disease glioblastoma multiforme pleiotropy cancer neurodegeneration |
| title | Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme |
| title_full | Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme |
| title_fullStr | Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme |
| title_full_unstemmed | Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme |
| title_short | Bidirectional Relation Between Parkinson's Disease and Glioblastoma Multiforme |
| title_sort | bidirectional relation between parkinson s disease and glioblastoma multiforme |
| topic | Parkinson's disease glioblastoma multiforme pleiotropy cancer neurodegeneration |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00898/full |
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