Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality
The molecular mechanisms underlying the development of posthemorrhagic hydrocephalus (PHH) remain incompletely understood. As the disease pathogenesis often cannot be attributed to visible cerebrospinal fluid (CSF) drainage obstructions, we here aimed to elucidate whether elevated CSF osmolality fol...
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/14/11476 |
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| author | Sara Diana Lolansen Nina Rostgaard Tenna Capion Nicolas H. Norager Markus Harboe Olsen Marianne Juhler Tiit Illimar Mathiesen Nanna MacAulay |
| author_facet | Sara Diana Lolansen Nina Rostgaard Tenna Capion Nicolas H. Norager Markus Harboe Olsen Marianne Juhler Tiit Illimar Mathiesen Nanna MacAulay |
| author_sort | Sara Diana Lolansen |
| collection | DOAJ |
| description | The molecular mechanisms underlying the development of posthemorrhagic hydrocephalus (PHH) remain incompletely understood. As the disease pathogenesis often cannot be attributed to visible cerebrospinal fluid (CSF) drainage obstructions, we here aimed to elucidate whether elevated CSF osmolality following subarachnoid hemorrhage (SAH) could potentiate the formation of ventricular fluid, and thereby contribute to the pathological CSF accumulation observed in PHH. The CSF osmolality was determined in 32 patients with acute SAH after external ventricular drainage (EVD) placement and again upon EVD removal and compared with the CSF osmolality from 14 healthy control subjects undergoing vascular clipping of an unruptured aneurism. However, we found no evidence of elevated CSF osmolality or electrolyte concentration in patients with SAH when compared to that of healthy control subjects. We detected no difference in CSF osmolality and electrolyte content in patients with successful EVD weaning versus those that were shunted due to PHH. Taken together, elevated CSF osmolality does not appear to underlie the development of PHH following SAH. The pathological CSF accumulation observed in this patient group must thus instead be attributed to other pathological alterations associated with the abnormal presence of blood within the CSF compartments following SAH. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:00:42Z |
| publishDate | 2023-07-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-72116d68d55a49d6b3bb76b35b2efe862023-11-18T19:40:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124141147610.3390/ijms241411476Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF OsmolalitySara Diana Lolansen0Nina Rostgaard1Tenna Capion2Nicolas H. Norager3Markus Harboe Olsen4Marianne Juhler5Tiit Illimar Mathiesen6Nanna MacAulay7Department of Neuroscience, University of Copenhagen, DK-2200 Copenhagen, DenmarkDepartment of Neurosurgery, University Hospital of Copenhagen—Rigshospitalet, DK-2100 Copenhagen, DenmarkDepartment of Neurosurgery, University Hospital of Copenhagen—Rigshospitalet, DK-2100 Copenhagen, DenmarkDepartment of Neurosurgery, University Hospital of Copenhagen—Rigshospitalet, DK-2100 Copenhagen, DenmarkDepartment of Neuroanaesthesiology, University Hospital of Copenhagen—Rigshospitalet, DK-2100 Copenhagen, DenmarkDepartment of Neurosurgery, University Hospital of Copenhagen—Rigshospitalet, DK-2100 Copenhagen, DenmarkDepartment of Neurosurgery, University Hospital of Copenhagen—Rigshospitalet, DK-2100 Copenhagen, DenmarkDepartment of Neuroscience, University of Copenhagen, DK-2200 Copenhagen, DenmarkThe molecular mechanisms underlying the development of posthemorrhagic hydrocephalus (PHH) remain incompletely understood. As the disease pathogenesis often cannot be attributed to visible cerebrospinal fluid (CSF) drainage obstructions, we here aimed to elucidate whether elevated CSF osmolality following subarachnoid hemorrhage (SAH) could potentiate the formation of ventricular fluid, and thereby contribute to the pathological CSF accumulation observed in PHH. The CSF osmolality was determined in 32 patients with acute SAH after external ventricular drainage (EVD) placement and again upon EVD removal and compared with the CSF osmolality from 14 healthy control subjects undergoing vascular clipping of an unruptured aneurism. However, we found no evidence of elevated CSF osmolality or electrolyte concentration in patients with SAH when compared to that of healthy control subjects. We detected no difference in CSF osmolality and electrolyte content in patients with successful EVD weaning versus those that were shunted due to PHH. Taken together, elevated CSF osmolality does not appear to underlie the development of PHH following SAH. The pathological CSF accumulation observed in this patient group must thus instead be attributed to other pathological alterations associated with the abnormal presence of blood within the CSF compartments following SAH.https://www.mdpi.com/1422-0067/24/14/11476cerebrospinal fluidosmolalitysubarachnoid hemorrhageposthemorrhagic hydrocephalus |
| spellingShingle | Sara Diana Lolansen Nina Rostgaard Tenna Capion Nicolas H. Norager Markus Harboe Olsen Marianne Juhler Tiit Illimar Mathiesen Nanna MacAulay Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality International Journal of Molecular Sciences cerebrospinal fluid osmolality subarachnoid hemorrhage posthemorrhagic hydrocephalus |
| title | Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality |
| title_full | Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality |
| title_fullStr | Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality |
| title_full_unstemmed | Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality |
| title_short | Posthemorrhagic Hydrocephalus in Patients with Subarachnoid Hemorrhage Occurs Independently of CSF Osmolality |
| title_sort | posthemorrhagic hydrocephalus in patients with subarachnoid hemorrhage occurs independently of csf osmolality |
| topic | cerebrospinal fluid osmolality subarachnoid hemorrhage posthemorrhagic hydrocephalus |
| url | https://www.mdpi.com/1422-0067/24/14/11476 |
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