Simultaneous CD8<sup>+</sup> T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs

Simultaneous CD8<sup>+</sup> T-Cell Immune Response against SARS-Cov-2 S, M, and N Induced by Endogenously Engineered Extracellular Vesicles in Both Spleen and Lungs

Most advanced vaccines against severe acute respiratory syndrome coronavirus (SARS-CoV)-2 are designed to induce antibodies against spike (S) protein. Differently, we developed an original strategy to induce CD8<sup>+</sup> T cytotoxic lymphocyte (CTL) immunity based on in vivo engineeri...

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Bibliographic Details
Main Authors: Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Andrea Giovannelli, Patrizia Leone, Maurizio Federico
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Vaccines
Subjects:
SARS-CoV-2
extracellular vesicles
CD8<sup>+</sup> T cell immunity
Nef
Online Access:https://www.mdpi.com/2076-393X/9/3/240

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