Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
Butti et al. generate a C9orf72 loss-of-function model in zebrafish. They find that that C9orf72 is required for presynaptic vesicle trafficking and release at the zebrafish larval neuromuscular junctions. This study provides functional insights into the pathogenesis of amyotrophic lateral sclerosis...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02302-y |
| _version_ | 1818735554937749504 |
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| author | Zoé Butti Yingzhou Edward Pan Jean Giacomotto Shunmoogum A. Patten |
| author_facet | Zoé Butti Yingzhou Edward Pan Jean Giacomotto Shunmoogum A. Patten |
| author_sort | Zoé Butti |
| collection | DOAJ |
| description | Butti et al. generate a C9orf72 loss-of-function model in zebrafish. They find that that C9orf72 is required for presynaptic vesicle trafficking and release at the zebrafish larval neuromuscular junctions. This study provides functional insights into the pathogenesis of amyotrophic lateral sclerosis and fronto-temporal dementia. |
| first_indexed | 2024-12-18T00:23:07Z |
| format | Article |
| id | doaj.art-721401a8b8eb4a4ea4abee48a68082dc |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-18T00:23:07Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-721401a8b8eb4a4ea4abee48a68082dc2022-12-21T21:27:17ZengNature PortfolioCommunications Biology2399-36422021-06-014111610.1038/s42003-021-02302-yReduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafishZoé Butti0Yingzhou Edward Pan1Jean Giacomotto2Shunmoogum A. Patten3INRS- Centre Armand-Frappier Santé BiotechnologieINRS- Centre Armand-Frappier Santé BiotechnologieQueensland Brain Institute, University of QueenslandINRS- Centre Armand-Frappier Santé BiotechnologieButti et al. generate a C9orf72 loss-of-function model in zebrafish. They find that that C9orf72 is required for presynaptic vesicle trafficking and release at the zebrafish larval neuromuscular junctions. This study provides functional insights into the pathogenesis of amyotrophic lateral sclerosis and fronto-temporal dementia.https://doi.org/10.1038/s42003-021-02302-y |
| spellingShingle | Zoé Butti Yingzhou Edward Pan Jean Giacomotto Shunmoogum A. Patten Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish Communications Biology |
| title | Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish |
| title_full | Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish |
| title_fullStr | Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish |
| title_full_unstemmed | Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish |
| title_short | Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish |
| title_sort | reduced c9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish |
| url | https://doi.org/10.1038/s42003-021-02302-y |
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