Central nervous system insulin signaling can influence the rate of insulin influx into brain

Abstract Background Insulin transport across the blood-brain barrier (BBB) is a highly regulated, saturable process, known to be affected by many peripheral substrates including insulin itself and triglycerides. This is in contrast to insulin leakage into peripheral tissues. Whether the central nerv...

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Bibliographic Details
Main Authors: Van Nguyen, Peter Thomas, Sarah Pemberton, Alice Babin, Cassidy Noonan, Riley Weaver, William A. Banks, Elizabeth M. Rhea
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Fluids and Barriers of the CNS
Subjects:
Online Access:https://doi.org/10.1186/s12987-023-00431-6