Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study
Therapeutic hypothermia (THT) is the recommended treatment for neuroprotection in (near) term newborns that experience perinatal asphyxia with hypoxic-ischemic encephalopathy. The benefit of THT in preterm newborns is unknown. This pilot study aims to investigate long-term outcomes of late preterm a...
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MDPI AG
2021-08-01
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| Online Access: | https://www.mdpi.com/2227-9032/9/8/994 |
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| author | Hanne Lademann Karl Abshagen Anna Janning Jan Däbritz Dirk Olbertz |
| author_facet | Hanne Lademann Karl Abshagen Anna Janning Jan Däbritz Dirk Olbertz |
| author_sort | Hanne Lademann |
| collection | DOAJ |
| description | Therapeutic hypothermia (THT) is the recommended treatment for neuroprotection in (near) term newborns that experience perinatal asphyxia with hypoxic-ischemic encephalopathy. The benefit of THT in preterm newborns is unknown. This pilot study aims to investigate long-term outcomes of late preterm asphyctic infants with and without THT compared to term infants. The single-center, retrospective analysis examined medical charts of infants with perinatal asphyxia born between 2008 and 2015. Long-term outcome was assessed using the Bayley Scales of Infant Development 2 at the age of (corrected) 24 months. Term (<i>n</i> = 31) and preterm (<i>n</i> = 8) infants with THT showed no differences regarding their long-term outcomes of psychomotor development (Psychomotor Developmental Index 101 ± 16 vs. 105 ± 11, <i>p</i> = 0.570), whereas preterm infants had a better mental outcome (Mental Developmental Index 105 ± 13 vs. 93 ± 18, <i>p</i> = 0.048). Preterm infants with and without (<i>n</i> = 69) THT showed a similar mental and psychomotor development (Mental Developmental Index 105 ± 13 vs. 96 ± 20, <i>p</i> = 0.527; Psychomotor Developmental Index 105 ± 11 vs. 105 ± 15, <i>p</i> = 0.927). The study highlights the importance of studying THT in asphyctic preterm infants. However, this study shows limitations and should not be used as a basis for decision-making in the clinical context. Results of a multicenter trial of THT for preterm infants (ID No.: CN-01540535) have to be awaited. |
| first_indexed | 2024-03-10T08:46:51Z |
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| language | English |
| last_indexed | 2024-03-10T08:46:51Z |
| publishDate | 2021-08-01 |
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| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-7214aeb1268a4aeeaf9e935a2cd211422023-11-22T07:49:17ZengMDPI AGHealthcare2227-90322021-08-019899410.3390/healthcare9080994Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot StudyHanne Lademann0Karl Abshagen1Anna Janning2Jan Däbritz3Dirk Olbertz4Department of Pediatrics, Rostock University Medical Center, 18057 Rostock, GermanyMedical School, Rostock University Medical Center, 18055 Rostock, GermanyMedical School, Rostock University Medical Center, 18055 Rostock, GermanyDepartment of Pediatrics, Rostock University Medical Center, 18057 Rostock, GermanyDepartment of Neonatology and Neonatal Intensive Care, Südstadt Hospital Rostock, 18059 Rostock, GermanyTherapeutic hypothermia (THT) is the recommended treatment for neuroprotection in (near) term newborns that experience perinatal asphyxia with hypoxic-ischemic encephalopathy. The benefit of THT in preterm newborns is unknown. This pilot study aims to investigate long-term outcomes of late preterm asphyctic infants with and without THT compared to term infants. The single-center, retrospective analysis examined medical charts of infants with perinatal asphyxia born between 2008 and 2015. Long-term outcome was assessed using the Bayley Scales of Infant Development 2 at the age of (corrected) 24 months. Term (<i>n</i> = 31) and preterm (<i>n</i> = 8) infants with THT showed no differences regarding their long-term outcomes of psychomotor development (Psychomotor Developmental Index 101 ± 16 vs. 105 ± 11, <i>p</i> = 0.570), whereas preterm infants had a better mental outcome (Mental Developmental Index 105 ± 13 vs. 93 ± 18, <i>p</i> = 0.048). Preterm infants with and without (<i>n</i> = 69) THT showed a similar mental and psychomotor development (Mental Developmental Index 105 ± 13 vs. 96 ± 20, <i>p</i> = 0.527; Psychomotor Developmental Index 105 ± 11 vs. 105 ± 15, <i>p</i> = 0.927). The study highlights the importance of studying THT in asphyctic preterm infants. However, this study shows limitations and should not be used as a basis for decision-making in the clinical context. Results of a multicenter trial of THT for preterm infants (ID No.: CN-01540535) have to be awaited.https://www.mdpi.com/2227-9032/9/8/994very low birth weightvery pretermhypoxic-ischemic encephalopathyBayley scales of infant developmentcooling |
| spellingShingle | Hanne Lademann Karl Abshagen Anna Janning Jan Däbritz Dirk Olbertz Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study Healthcare very low birth weight very preterm hypoxic-ischemic encephalopathy Bayley scales of infant development cooling |
| title | Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study |
| title_full | Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study |
| title_fullStr | Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study |
| title_full_unstemmed | Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study |
| title_short | Long-Term Outcome after Asphyxia and Therapeutic Hypothermia in Late Preterm Infants: A Pilot Study |
| title_sort | long term outcome after asphyxia and therapeutic hypothermia in late preterm infants a pilot study |
| topic | very low birth weight very preterm hypoxic-ischemic encephalopathy Bayley scales of infant development cooling |
| url | https://www.mdpi.com/2227-9032/9/8/994 |
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