Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient
Neurodegenerative diseases and various other chronic ailments have gradually transformed into public-health issues. Neurodegenerative disorders are a range of progressive neural abnormalities characterized by cellular dysfunctions, neuronal structure, and function loss. Among many chronic disorders,...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222006886 |
| _version_ | 1811188100310761472 |
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| author | Gadde Shareena Dileep Kumar |
| author_facet | Gadde Shareena Dileep Kumar |
| author_sort | Gadde Shareena |
| collection | DOAJ |
| description | Neurodegenerative diseases and various other chronic ailments have gradually transformed into public-health issues. Neurodegenerative disorders are a range of progressive neural abnormalities characterized by cellular dysfunctions, neuronal structure, and function loss. Among many chronic disorders, oxidative stress, inflammation, mitochondrial dysregulation, and cellular alterations in the human body are considered the most prevalent diagnostic symptoms. They have a profound impact on patients' health and wellbeing. The disease's poor curability, high healthcare costs, and lethality are the principal reasons for approaching and exploring the conventional treatment's phytotherapeutic alternatives. Ginkgo biloba (Maidenhair tree) is a well-known and widely used herbal plant in the Ginkgoaceae family. Its phytochemical constituents, Flavonoids, and terpenes, have been identified as the primary ingredients of Ginkgo biloba leaf extracts. It has been widely used due to its therapeutic properties, including its neuroprotective, anti-dementia, antioxidant, anti-inflammatory, vasoactive, anti-psychotic, anti-neoplastic, and anti-platelet activity. In recent decades, plenty of Ginkgo-derived substances has been researched and elucidated to have significant therapeutic effects in numerous disease models. This review aims to provide a thorough understanding of the botanical basis for Ginkgo biloba, its usage as herbal medicine, and its pivotal role in functional foods. Additionally, the clinical significance of Ginkgo biloba, as observed in various research works and clinical investigations, is also emphasized, facilitating a better understanding of their molecular basis and application in many chronic diseases. |
| first_indexed | 2024-04-11T14:14:39Z |
| format | Article |
| id | doaj.art-7217161ef455494dba8c75d5addf90da |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:14:39Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-7217161ef455494dba8c75d5addf90da2022-12-22T04:19:36ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113299Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredientGadde Shareena0Dileep Kumar1Poona College of Pharmacy, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be University), Erandwane, Pune 411038, Maharashtra, IndiaCorresponding author.; Poona College of Pharmacy, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be University), Erandwane, Pune 411038, Maharashtra, IndiaNeurodegenerative diseases and various other chronic ailments have gradually transformed into public-health issues. Neurodegenerative disorders are a range of progressive neural abnormalities characterized by cellular dysfunctions, neuronal structure, and function loss. Among many chronic disorders, oxidative stress, inflammation, mitochondrial dysregulation, and cellular alterations in the human body are considered the most prevalent diagnostic symptoms. They have a profound impact on patients' health and wellbeing. The disease's poor curability, high healthcare costs, and lethality are the principal reasons for approaching and exploring the conventional treatment's phytotherapeutic alternatives. Ginkgo biloba (Maidenhair tree) is a well-known and widely used herbal plant in the Ginkgoaceae family. Its phytochemical constituents, Flavonoids, and terpenes, have been identified as the primary ingredients of Ginkgo biloba leaf extracts. It has been widely used due to its therapeutic properties, including its neuroprotective, anti-dementia, antioxidant, anti-inflammatory, vasoactive, anti-psychotic, anti-neoplastic, and anti-platelet activity. In recent decades, plenty of Ginkgo-derived substances has been researched and elucidated to have significant therapeutic effects in numerous disease models. This review aims to provide a thorough understanding of the botanical basis for Ginkgo biloba, its usage as herbal medicine, and its pivotal role in functional foods. Additionally, the clinical significance of Ginkgo biloba, as observed in various research works and clinical investigations, is also emphasized, facilitating a better understanding of their molecular basis and application in many chronic diseases.http://www.sciencedirect.com/science/article/pii/S0753332222006886Ginkgo bilobaNeuroprotectantEGb 761Anti-dementiaAnti-diabeticBiomarkers |
| spellingShingle | Gadde Shareena Dileep Kumar Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient Biomedicine & Pharmacotherapy Ginkgo biloba Neuroprotectant EGb 761 Anti-dementia Anti-diabetic Biomarkers |
| title | Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient |
| title_full | Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient |
| title_fullStr | Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient |
| title_full_unstemmed | Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient |
| title_short | Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient |
| title_sort | traversing through half a century research timeline on ginkgo biloba in transforming a botanical rarity into an active functional food ingredient |
| topic | Ginkgo biloba Neuroprotectant EGb 761 Anti-dementia Anti-diabetic Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222006886 |
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