Successful management of rocuronium-induced anaphylaxis with sugammadex: A case report
Although anaphylaxis during anaesthesia is a rare event, neuromuscular blocking drugs are responsible for 62% of anaesthesia-related anaphylaxis. However, sugammadex, a modified gamma-cyclodextrin, can encapsulate rocuronium molecules and cause the rapid reversal of the neuromuscular blockade. A 68-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-07-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221113913 |
| _version_ | 1818189840701718528 |
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| author | Sheng-Kai Hung Chia-Chi Yeh Pei-Chi Ting Cay-Huyen Chen Ming-Chang Kao |
| author_facet | Sheng-Kai Hung Chia-Chi Yeh Pei-Chi Ting Cay-Huyen Chen Ming-Chang Kao |
| author_sort | Sheng-Kai Hung |
| collection | DOAJ |
| description | Although anaphylaxis during anaesthesia is a rare event, neuromuscular blocking drugs are responsible for 62% of anaesthesia-related anaphylaxis. However, sugammadex, a modified gamma-cyclodextrin, can encapsulate rocuronium molecules and cause the rapid reversal of the neuromuscular blockade. A 68-year-old man who presented for a radical prostatectomy was induced with IV fentanyl/propofol/rocuronium. He had not received rocuronium previously but had received cisatracurium. Shortly after anaesthesia, the patient’s heart rate abruptly increased, and systolic blood pressure (SBP) dropped to 40 mm Hg. Despite cardiopulmonary resuscitation and intensive management, his haemodynamic stability did not improve until he received IV sugammadex, 200 mg. Intradermal skin tests showed he was positive for cisatracurium, rocuronium and succinylcholine. The patient was suspected to have cross-reactivity of rocuronium with cisatracurium. This case highlights the potential benefit of sugammadex as an adjunct to conventional measures during rocuronium-induced anaphylaxis. |
| first_indexed | 2024-12-11T23:49:13Z |
| format | Article |
| id | doaj.art-7218e7ed0f514cada88049b2b43d7c4d |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-11T23:49:13Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-7218e7ed0f514cada88049b2b43d7c4d2022-12-22T00:45:31ZengSAGE PublishingJournal of International Medical Research1473-23002022-07-015010.1177/03000605221113913Successful management of rocuronium-induced anaphylaxis with sugammadex: A case reportSheng-Kai HungChia-Chi YehPei-Chi TingCay-Huyen ChenMing-Chang KaoAlthough anaphylaxis during anaesthesia is a rare event, neuromuscular blocking drugs are responsible for 62% of anaesthesia-related anaphylaxis. However, sugammadex, a modified gamma-cyclodextrin, can encapsulate rocuronium molecules and cause the rapid reversal of the neuromuscular blockade. A 68-year-old man who presented for a radical prostatectomy was induced with IV fentanyl/propofol/rocuronium. He had not received rocuronium previously but had received cisatracurium. Shortly after anaesthesia, the patient’s heart rate abruptly increased, and systolic blood pressure (SBP) dropped to 40 mm Hg. Despite cardiopulmonary resuscitation and intensive management, his haemodynamic stability did not improve until he received IV sugammadex, 200 mg. Intradermal skin tests showed he was positive for cisatracurium, rocuronium and succinylcholine. The patient was suspected to have cross-reactivity of rocuronium with cisatracurium. This case highlights the potential benefit of sugammadex as an adjunct to conventional measures during rocuronium-induced anaphylaxis.https://doi.org/10.1177/03000605221113913 |
| spellingShingle | Sheng-Kai Hung Chia-Chi Yeh Pei-Chi Ting Cay-Huyen Chen Ming-Chang Kao Successful management of rocuronium-induced anaphylaxis with sugammadex: A case report Journal of International Medical Research |
| title | Successful management of rocuronium-induced anaphylaxis with sugammadex: A case report |
| title_full | Successful management of rocuronium-induced anaphylaxis with sugammadex: A case report |
| title_fullStr | Successful management of rocuronium-induced anaphylaxis with sugammadex: A case report |
| title_full_unstemmed | Successful management of rocuronium-induced anaphylaxis with sugammadex: A case report |
| title_short | Successful management of rocuronium-induced anaphylaxis with sugammadex: A case report |
| title_sort | successful management of rocuronium induced anaphylaxis with sugammadex a case report |
| url | https://doi.org/10.1177/03000605221113913 |
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