Optimizing the mechanical and surface topography of hydroxyapatite/Gd2O3/graphene oxide nanocomposites for medical applications
A ternary nanocomposite (TNC) was fabricated for introducing multifunctional properties for various biomedical applications. The nanocomposites consist of hydroxyapatite (HAP) combined with/without graphene oxide (GO) and gadolinium oxide (Gd2O3). The lattice constants of HAP were around 9.4285 and...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S131961032200045X |
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| author | M.A. El-Morsy Nasser S. Awwad Hala A. Ibrahium Walaa Alharbi Mohammad Y. Alshahrani A.A. Menazea |
| author_facet | M.A. El-Morsy Nasser S. Awwad Hala A. Ibrahium Walaa Alharbi Mohammad Y. Alshahrani A.A. Menazea |
| author_sort | M.A. El-Morsy |
| collection | DOAJ |
| description | A ternary nanocomposite (TNC) was fabricated for introducing multifunctional properties for various biomedical applications. The nanocomposites consist of hydroxyapatite (HAP) combined with/without graphene oxide (GO) and gadolinium oxide (Gd2O3). The lattice constants of HAP were around 9.4285 and 6.7476 Å, while for Gd2O3 was around 10.8441 Å. The morphological investigation detected the nanosheets of GO, and nanorods of HAP/Gd2O3 with length of 27 nm. Moreover, the topological study based on a field emission scanning electron microscope (FESEM) showed that HAP/GO had average roughness (Ra) of 4.8 nm, and the root mean square value (Rq) with a value of 7 nm. Furthermore, the average pore size reached 7.99 nm for the NC of HAP/GO. In addition, the cumulative surface area using the density functional theory (DFT) method was calculated at around 44.61 m2/g for TNC. The cell viability in vitro of osteoblast cell line improved from 95.6 ± 0.6% to 96.7 ± 0.5% which indicates the biocompatibility of the implants to be used in biomedical applications. |
| first_indexed | 2024-04-13T22:16:29Z |
| format | Article |
| id | doaj.art-721d7dafd31144f49554fea4f83e3941 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-04-13T22:16:29Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-721d7dafd31144f49554fea4f83e39412022-12-22T02:27:30ZengElsevierJournal of Saudi Chemical Society1319-61032022-05-01263101463Optimizing the mechanical and surface topography of hydroxyapatite/Gd2O3/graphene oxide nanocomposites for medical applicationsM.A. El-Morsy0Nasser S. Awwad1Hala A. Ibrahium2Walaa Alharbi3Mohammad Y. Alshahrani4A.A. Menazea5College of Science and Humanities in Al-Kharj, Physics Department, Plasma Technology and Material Science Unit, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia; Physics Department, Faculty of Science, University of Damietta, New Damietta 34517, Egypt; Corresponding author at: College of Science and Humanities in Al-Kharj, Physics Department, Plasma Technology and Material Science Unit, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi ArabiaChemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi ArabiaBiology Department, Faculty of Science , King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia; Department of Semi Pilot Plant, Nuclear Materials Authority, P.O. Box 530, El Maadi, EgyptDepartment of Chemistry, Science and Arts College, King Abdulaziz University, Rabigh, Saudi ArabiaDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, Abha 9088, Saudi ArabiaLaser Technology Unit, Center of Excellent for Advanced Science, National Research Centre, Dokki, 12622 Giza, Egypt; Spectroscopy Department, Physics Research Institute, National Research Centre, Dokki, 12622 Giza, EgyptA ternary nanocomposite (TNC) was fabricated for introducing multifunctional properties for various biomedical applications. The nanocomposites consist of hydroxyapatite (HAP) combined with/without graphene oxide (GO) and gadolinium oxide (Gd2O3). The lattice constants of HAP were around 9.4285 and 6.7476 Å, while for Gd2O3 was around 10.8441 Å. The morphological investigation detected the nanosheets of GO, and nanorods of HAP/Gd2O3 with length of 27 nm. Moreover, the topological study based on a field emission scanning electron microscope (FESEM) showed that HAP/GO had average roughness (Ra) of 4.8 nm, and the root mean square value (Rq) with a value of 7 nm. Furthermore, the average pore size reached 7.99 nm for the NC of HAP/GO. In addition, the cumulative surface area using the density functional theory (DFT) method was calculated at around 44.61 m2/g for TNC. The cell viability in vitro of osteoblast cell line improved from 95.6 ± 0.6% to 96.7 ± 0.5% which indicates the biocompatibility of the implants to be used in biomedical applications.http://www.sciencedirect.com/science/article/pii/S131961032200045XGd2O3Graphene oxideHydroxyapatiteAntibacterialBone scaffolding |
| spellingShingle | M.A. El-Morsy Nasser S. Awwad Hala A. Ibrahium Walaa Alharbi Mohammad Y. Alshahrani A.A. Menazea Optimizing the mechanical and surface topography of hydroxyapatite/Gd2O3/graphene oxide nanocomposites for medical applications Journal of Saudi Chemical Society Gd2O3 Graphene oxide Hydroxyapatite Antibacterial Bone scaffolding |
| title | Optimizing the mechanical and surface topography of hydroxyapatite/Gd2O3/graphene oxide nanocomposites for medical applications |
| title_full | Optimizing the mechanical and surface topography of hydroxyapatite/Gd2O3/graphene oxide nanocomposites for medical applications |
| title_fullStr | Optimizing the mechanical and surface topography of hydroxyapatite/Gd2O3/graphene oxide nanocomposites for medical applications |
| title_full_unstemmed | Optimizing the mechanical and surface topography of hydroxyapatite/Gd2O3/graphene oxide nanocomposites for medical applications |
| title_short | Optimizing the mechanical and surface topography of hydroxyapatite/Gd2O3/graphene oxide nanocomposites for medical applications |
| title_sort | optimizing the mechanical and surface topography of hydroxyapatite gd2o3 graphene oxide nanocomposites for medical applications |
| topic | Gd2O3 Graphene oxide Hydroxyapatite Antibacterial Bone scaffolding |
| url | http://www.sciencedirect.com/science/article/pii/S131961032200045X |
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