Identification of aryl hydrocarbon receptor as a barrier to HIV-1 infection and outgrowth in CD4+ T cells
Summary: The aryl hydrocarbon receptor (AhR) regulates Th17-polarized CD4+ T cell functions, but its role in HIV-1 replication/outgrowth remains unknown. Genetic (CRISPR-Cas9) and pharmacological inhibition reveal AhR as a barrier to HIV-1 replication in T cell receptor (TCR)-activated CD4+ T cells...
Main Authors: | Debashree Chatterjee, Yuwei Zhang, Christ-Dominique Ngassaki-Yoka, Antoine Dutilleul, Soumia Khalfi, Olivier Hernalsteens, Tomas Raul Wiche Salinas, Jonathan Dias, Huicheng Chen, Yasmine Smail, Jean-Philippe Goulet, Brendan Bell, Jean-Pierre Routy, Carine Van Lint, Petronela Ancuta |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-06-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723006459 |
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