Identification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis

Identification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis

Abstract Oral submucous fibrosis (OSF) is a chronic and insidious oral potentially malignant disorder associated with a 4–17% risk of oral squamous cell carcinoma (OSCC). Our previous study found that proteasomal activator 28 gamma (PA28γ) is frequently overexpressed in oral squamous cell carcinoma...

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Main Authors: Changqing Xie, Zaiye Li, Yufei Hua, Silu Sun, Liang Zhong, Qian Chen, Hui Feng, Ning Ji, Taiwen Li, Xikun Zhou, Xin Zeng, Zhangui Tang, Chongkui Sun, Jing Li, Qianming Chen
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05152-6

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