Heteroaryl derivatives of suvorexant as OX1R selective PET ligand candidates: Cu-mediated 18F-fluorination of boroxines, in vitro and initial in vivo evaluation

Heteroaryl derivatives of suvorexant as OX1R selective PET ligand candidates: Cu-mediated 18F-fluorination of boroxines, in vitro and initial in vivo evaluation

Abstract Background The orexin receptor (OXR) plays a role in drug addiction and is aberrantly expressed in colorectal tumors. Subtype-selective OXR PET ligands suitable for in vivo use have not yet been reported. This work reports the development of 18F-labeled OXR PET ligand candidates derived fro...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Kim-Viktoria Bolik, Jan Hellmann, Simone Maschauer, Eduard Neu, Jürgen Einsiedel, Patrick Riss, Nora Vogg, Jörg König, Martin F. Fromm, Harald Hübner, Peter Gmeiner, Olaf Prante
Format: Artikel
Sprache:English
Veröffentlicht: SpringerOpen 2024-09-01
Schriftenreihe:EJNMMI Research
Schlagworte:
Orexin receptor
Suvorexant
F-18
Cu-mediated 18F-fluorination
PET
Online Zugang:https://doi.org/10.1186/s13550-024-01141-2

Online

https://doi.org/10.1186/s13550-024-01141-2

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