Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity

Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity

Activation of group III metabotropic glutamate (mGlu) receptors has been recently highlighted as a potential approach in the treatment of Parkinson's disease (PD). This study evaluates the antiparkinsonian action of systemic administration of the broad-spectrum agonist of group III mGlu recepto...

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Bibliographic Details
Main Authors: S. Lopez, L. Jouve, N. Turle-Lorenzo, L. Kerkerian-LeGoff, P. Salin, M. Amalric
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neurobiology of Disease
Subjects:
Basal ganglia
6-Hydroxydopamine (6-OHDA)
Glutamate
Reaction time task
In situ hybridization
Rat
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111004311

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