A Retrospective Study of the Effects of SARS-CoV-2 Positivity on the Development of Nosocomial Infections in Patients Treated in the Intensive Care Unit
Introduction: Nosocomial infections (NI) increase morbidity and mortality in patients in the COVID-19 ICU. In this study, it was aimed to determine the risk factors for nosocomial infections in patients treated in the COVID-19 ICU. Materials and Methods: Patients who were treated in the COVID-19 a...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2023-06-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://www.floradergisi.org/managete/fu_folder/2023-02/2023-28-02-144-155.pdf |
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| author | Gülşen ÜNAL Zeynep TÜRE Gamze KALIN ÜNÜVAR Aynur KARAYOL AKIN Aliye ESMAOĞLU Ayşe ÜLGEY Ayşegül ULU KILIÇ |
| author_facet | Gülşen ÜNAL Zeynep TÜRE Gamze KALIN ÜNÜVAR Aynur KARAYOL AKIN Aliye ESMAOĞLU Ayşe ÜLGEY Ayşegül ULU KILIÇ |
| author_sort | Gülşen ÜNAL |
| collection | DOAJ |
| description | Introduction: Nosocomial infections (NI) increase morbidity and mortality in patients in the COVID-19 ICU. In this study, it was aimed to determine the risk factors for nosocomial infections in patients treated in the COVID-19 ICU.
Materials and Methods: Patients who were treated in the COVID-19 and non-COVID-19 ICU between March 2020 and June 2021 were analyzed retrospectively. Demographic data, chronic diseases, invasive procedures and risk factors were compared between patients with and without NI.
Results: The study included 174 patients, and 84 from COVID-19 ICU. The median age of the patients was 66.5 (21-92) and the male gender rate was 56.9%. The frequency of hospitalization in the last three months and the mean Charlson comorbidity index were higher in patients treated in the COVID-19 ICU (p= 0.001). Presence of any nosocomial infection (64% vs 46%), rate of nosocomial pneumonia (10.7% vs. 2.2%), and catheter-related bloodstream infection rate were higher in the COVID-19 ICU. The 14-day mortality rates were 57% in the COVID-19 ICU, while it was 33% in the non-COVID-19 ICU (p=0.002). Advanced age [OR=0.97 (95% CI= 0.94-1.0) p= 0.049], prolonged stay in the ICU [OR= 1.28 (95% CI= 1.16-1.41) p=0.001], chronic kidney disease [OR= 10.57 (95% CI= 2.02-54.56) p= 0.05], and coronary artery disease [OR= 4.61 (95% CI= 1.44-14.79) p= 0.010] were found to be risk factors for NI, while other risk factors were enteral nutrition [OR= 2.69 (95% CI= 1.03-7.04) p= 0.043], central catheter [OR= 4.60 (95% CI= 1.88-11.22) p= 0.001] and a history of hospitalization in the ICU in the last three months [OR= 3.59 (95% CI= 1.01-12.83) p= 0.048]. Risk factors for NI in the COVID-19 ICU include prolonged ICU stay and enteral nutrition.
Conclusion: The presence of COVID-19 in patients treated in the ICU is important . Long-term ICU follow-up, invasive procedures and enteral nutrition practices are important risk factors for the development of NI in patients with a diagnosis of COVID-19.
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| first_indexed | 2024-03-12T02:17:06Z |
| format | Article |
| id | doaj.art-7224461ce5214ec6a10915cac1ae1a6f |
| institution | Directory Open Access Journal |
| issn | 1300-932X |
| language | English |
| last_indexed | 2024-03-12T02:17:06Z |
| publishDate | 2023-06-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-7224461ce5214ec6a10915cac1ae1a6f2023-09-06T07:28:28ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X2023-06-0128214415510.5578/flora.20239914A Retrospective Study of the Effects of SARS-CoV-2 Positivity on the Development of Nosocomial Infections in Patients Treated in the Intensive Care UnitGülşen ÜNAL0https://orcid.org/0000-0002-4125-597XZeynep TÜRE1https://orcid.org/0000-0001-6895-0318Gamze KALIN ÜNÜVAR2https://orcid.org/0000-0001-7209-8826Aynur KARAYOL AKIN3https://orcid.org/0000-0001-9193-683XAliye ESMAOĞLU4https://orcid.org/0000-0002-8267-138XAyşe ÜLGEY5https://orcid.org/0000-0002-7634-6214Ayşegül ULU KILIÇ6https://orcid.org/0000-0002-4454-374XErciyes Üniversitesi Tıp Fakültesi, İnfeksiyon Kontrol Kurulu, Kayseri, TürkiyeErciyes Üniversitesi Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Kayseri, TürkiyeErciyes Üniversitesi Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Kayseri, TürkiyeErciyes Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Kayseri, TürkiyeErciyes Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Kayseri, TürkiyeErciyes Üniversitesi Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Anabilim Dalı, Kayseri, TürkiyeErciyes Üniversitesi Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Kayseri, TürkiyeIntroduction: Nosocomial infections (NI) increase morbidity and mortality in patients in the COVID-19 ICU. In this study, it was aimed to determine the risk factors for nosocomial infections in patients treated in the COVID-19 ICU. Materials and Methods: Patients who were treated in the COVID-19 and non-COVID-19 ICU between March 2020 and June 2021 were analyzed retrospectively. Demographic data, chronic diseases, invasive procedures and risk factors were compared between patients with and without NI. Results: The study included 174 patients, and 84 from COVID-19 ICU. The median age of the patients was 66.5 (21-92) and the male gender rate was 56.9%. The frequency of hospitalization in the last three months and the mean Charlson comorbidity index were higher in patients treated in the COVID-19 ICU (p= 0.001). Presence of any nosocomial infection (64% vs 46%), rate of nosocomial pneumonia (10.7% vs. 2.2%), and catheter-related bloodstream infection rate were higher in the COVID-19 ICU. The 14-day mortality rates were 57% in the COVID-19 ICU, while it was 33% in the non-COVID-19 ICU (p=0.002). Advanced age [OR=0.97 (95% CI= 0.94-1.0) p= 0.049], prolonged stay in the ICU [OR= 1.28 (95% CI= 1.16-1.41) p=0.001], chronic kidney disease [OR= 10.57 (95% CI= 2.02-54.56) p= 0.05], and coronary artery disease [OR= 4.61 (95% CI= 1.44-14.79) p= 0.010] were found to be risk factors for NI, while other risk factors were enteral nutrition [OR= 2.69 (95% CI= 1.03-7.04) p= 0.043], central catheter [OR= 4.60 (95% CI= 1.88-11.22) p= 0.001] and a history of hospitalization in the ICU in the last three months [OR= 3.59 (95% CI= 1.01-12.83) p= 0.048]. Risk factors for NI in the COVID-19 ICU include prolonged ICU stay and enteral nutrition. Conclusion: The presence of COVID-19 in patients treated in the ICU is important . Long-term ICU follow-up, invasive procedures and enteral nutrition practices are important risk factors for the development of NI in patients with a diagnosis of COVID-19. http://www.floradergisi.org/managete/fu_folder/2023-02/2023-28-02-144-155.pdfcovid-19catheter-associated bloodstream infectionnosocomial infection; sars-cov-2ventilator-associated pneumoniaintensive care unit |
| spellingShingle | Gülşen ÜNAL Zeynep TÜRE Gamze KALIN ÜNÜVAR Aynur KARAYOL AKIN Aliye ESMAOĞLU Ayşe ÜLGEY Ayşegül ULU KILIÇ A Retrospective Study of the Effects of SARS-CoV-2 Positivity on the Development of Nosocomial Infections in Patients Treated in the Intensive Care Unit Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi covid-19 catheter-associated bloodstream infection nosocomial infection; sars-cov-2 ventilator-associated pneumonia intensive care unit |
| title | A Retrospective Study of the Effects of SARS-CoV-2 Positivity on the Development of Nosocomial Infections in Patients Treated in the Intensive Care Unit |
| title_full | A Retrospective Study of the Effects of SARS-CoV-2 Positivity on the Development of Nosocomial Infections in Patients Treated in the Intensive Care Unit |
| title_fullStr | A Retrospective Study of the Effects of SARS-CoV-2 Positivity on the Development of Nosocomial Infections in Patients Treated in the Intensive Care Unit |
| title_full_unstemmed | A Retrospective Study of the Effects of SARS-CoV-2 Positivity on the Development of Nosocomial Infections in Patients Treated in the Intensive Care Unit |
| title_short | A Retrospective Study of the Effects of SARS-CoV-2 Positivity on the Development of Nosocomial Infections in Patients Treated in the Intensive Care Unit |
| title_sort | retrospective study of the effects of sars cov 2 positivity on the development of nosocomial infections in patients treated in the intensive care unit |
| topic | covid-19 catheter-associated bloodstream infection nosocomial infection; sars-cov-2 ventilator-associated pneumonia intensive care unit |
| url | http://www.floradergisi.org/managete/fu_folder/2023-02/2023-28-02-144-155.pdf |
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