Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study
Abstract Background The purpose of this study is to investigate the association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers. Methods A case–control study was conducted in the Tangsteel company in Tangshan, Chi...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-023-09328-y |
| _version_ | 1797832228403675136 |
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| author | Qinglin Li Shengkui Zhang Han Wang Zhende Wang Xiaohong Zhang Yongbin Wang Juxiang Yuan |
| author_facet | Qinglin Li Shengkui Zhang Han Wang Zhende Wang Xiaohong Zhang Yongbin Wang Juxiang Yuan |
| author_sort | Qinglin Li |
| collection | DOAJ |
| description | Abstract Background The purpose of this study is to investigate the association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers. Methods A case–control study was conducted in the Tangsteel company in Tangshan, China. The sample sizes of the case group and control group were 251 and 451, respectively. The logistic regression, log-linear model and generalized multifactor dimensionality (GMDR) method were used to investigate the interaction between circadian clock gene, melatonin receptor genes and rotating night shift work on type 2 diabetes among steelworkers. Relative excess risk due to interaction (RERI) and attributable proportions (AP) were used to evaluate additive interactions. Results Rotating night shift work, current shift status, duration of night shifts, and average frequency of night shifts were associated with an increased risk of type 2 diabetes after adjustment for confounders. Rs1387153 variants in MTNR1B was found to be associated with an increased risk of type 2 diabetes, which was not found between MTNR1A gene rs2119882 locus, CLOCK gene rs1801260 locus and the risk of type 2 diabetes. The association between rotating night shift work and risk of type 2 diabetes appeared to be modified by MTNR1B gene rs1387153 locus (RERI = 0.98, (95% CI, 0.40–1.55); AP = 0.60, (95% CI, 0.07–1.12)). The interaction between MTNR1A gene rs2119882 locus and CLOCK gene rs1801260 locus was associated with the risk of type 2 diabetes (RERI = 1.07, (95% CI, 0.23–1.91); AP = 0.77, (95% CI, 0.36–1.17)). The complex interaction of the MTNR1A-MTNR1B-CLOCK-rotating night shift work model based on the GMDR methods may increase the risk of type 2 diabetes (P = 0.011). Conclusions Rotating night shift work and rs1387153 variants in MTNR1B were associated with an increased risk of type 2 diabetes among steelworkers. The complex interaction of MTNR1A-MTNR1B-CLOCK-rotating night shift work may increase the risk of type 2 diabetes. |
| first_indexed | 2024-04-09T14:04:26Z |
| format | Article |
| id | doaj.art-7224b363a61340979ce07e4375915bf9 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-04-09T14:04:26Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
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| series | BMC Genomics |
| spelling | doaj.art-7224b363a61340979ce07e4375915bf92023-05-07T11:06:37ZengBMCBMC Genomics1471-21642023-05-0124111310.1186/s12864-023-09328-yAssociation of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control studyQinglin Li0Shengkui Zhang1Han Wang2Zhende Wang3Xiaohong Zhang4Yongbin Wang5Juxiang Yuan6Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and TechnologyDepartment of Epidemiology and Health Statistics, School of Public Health, North China University of Science and TechnologyTianjin Baodi District Center for Disease ControlDepartment of Public Health Crisis Management, School of Public Health, Shandong Province, Weifang Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, North China University of Science and TechnologyDepartment of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, North China University of Science and TechnologyAbstract Background The purpose of this study is to investigate the association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers. Methods A case–control study was conducted in the Tangsteel company in Tangshan, China. The sample sizes of the case group and control group were 251 and 451, respectively. The logistic regression, log-linear model and generalized multifactor dimensionality (GMDR) method were used to investigate the interaction between circadian clock gene, melatonin receptor genes and rotating night shift work on type 2 diabetes among steelworkers. Relative excess risk due to interaction (RERI) and attributable proportions (AP) were used to evaluate additive interactions. Results Rotating night shift work, current shift status, duration of night shifts, and average frequency of night shifts were associated with an increased risk of type 2 diabetes after adjustment for confounders. Rs1387153 variants in MTNR1B was found to be associated with an increased risk of type 2 diabetes, which was not found between MTNR1A gene rs2119882 locus, CLOCK gene rs1801260 locus and the risk of type 2 diabetes. The association between rotating night shift work and risk of type 2 diabetes appeared to be modified by MTNR1B gene rs1387153 locus (RERI = 0.98, (95% CI, 0.40–1.55); AP = 0.60, (95% CI, 0.07–1.12)). The interaction between MTNR1A gene rs2119882 locus and CLOCK gene rs1801260 locus was associated with the risk of type 2 diabetes (RERI = 1.07, (95% CI, 0.23–1.91); AP = 0.77, (95% CI, 0.36–1.17)). The complex interaction of the MTNR1A-MTNR1B-CLOCK-rotating night shift work model based on the GMDR methods may increase the risk of type 2 diabetes (P = 0.011). Conclusions Rotating night shift work and rs1387153 variants in MTNR1B were associated with an increased risk of type 2 diabetes among steelworkers. The complex interaction of MTNR1A-MTNR1B-CLOCK-rotating night shift work may increase the risk of type 2 diabetes.https://doi.org/10.1186/s12864-023-09328-yRotating night shift workCircadian rhythmMelatonin receptorsPolymorphismsInteraction |
| spellingShingle | Qinglin Li Shengkui Zhang Han Wang Zhende Wang Xiaohong Zhang Yongbin Wang Juxiang Yuan Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study BMC Genomics Rotating night shift work Circadian rhythm Melatonin receptors Polymorphisms Interaction |
| title | Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study |
| title_full | Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study |
| title_fullStr | Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study |
| title_full_unstemmed | Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study |
| title_short | Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study |
| title_sort | association of rotating night shift work clock mtnr1a mtnr1b genes polymorphisms and their interactions with type 2 diabetes among steelworkers a case control study |
| topic | Rotating night shift work Circadian rhythm Melatonin receptors Polymorphisms Interaction |
| url | https://doi.org/10.1186/s12864-023-09328-y |
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