Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of Fluoxetine
Herein, we present a new validated potentiometric method for fluoxetine (FLX) drug monitoring. The method is based on the integration of molecular imprinting polymer (MIP) beads as sensory elements with modified screen-printed solid contact ion-selective electrodes (ISEs). A multi-walled carbon nano...
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MDPI AG
2020-03-01
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Online Access: | https://www.mdpi.com/2079-4991/10/3/572 |
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author | Saad S.M. Hassan Ayman H. Kamel Abd El-Galil E. Amr Heba M. Hashem E.M. Abdel Bary |
author_facet | Saad S.M. Hassan Ayman H. Kamel Abd El-Galil E. Amr Heba M. Hashem E.M. Abdel Bary |
author_sort | Saad S.M. Hassan |
collection | DOAJ |
description | Herein, we present a new validated potentiometric method for fluoxetine (FLX) drug monitoring. The method is based on the integration of molecular imprinting polymer (MIP) beads as sensory elements with modified screen-printed solid contact ion-selective electrodes (ISEs). A multi-walled carbon nanotube (MWCNT) was used as a nanomaterial for the ion-to-electron transduction process. The prepared MIP beads depend on the use of acrylamide (AAm) and ethylene glycol dimethacrylic acid (EGDMA) as a functional monomer and cross-linker, respectively. The sensor revealed a stable response with a Nernstian slope of 58.9 ± 0.2 mV/decade and a detection limit of 2.1 × 10<sup>−6</sup> mol/L in 10 mmol/L acetate buffer of pH 4.5. The presented miniaturized sensors revealed good selectivity towards FLX over many organic and inorganic cations, as well as some additives encountered in the pharmaceutical preparations. Repeatability, reproducibility and stability have been studied to evaluate the analytical features of the presented sensors. These sensors were successfully applied for FLX assessment in different pharmaceutical formulations collected from the Egyptian local market. The obtained results agreed well with the acceptable recovery percentage and were better than those obtained by other previously reported routine methods. |
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language | English |
last_indexed | 2024-04-13T09:56:40Z |
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spelling | doaj.art-722596285f6f4b95be772190e877921c2022-12-22T02:51:21ZengMDPI AGNanomaterials2079-49912020-03-0110357210.3390/nano10030572nano10030572Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of FluoxetineSaad S.M. Hassan0Ayman H. Kamel1Abd El-Galil E. Amr2Heba M. Hashem3E.M. Abdel Bary4Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo 11566, EgyptChemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo 11566, EgyptPharmaceutical Chemistry Department, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaChemistry Department, Faculty of Science, Ain Shams University, Abbasia, Cairo 11566, EgyptChemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, EgyptHerein, we present a new validated potentiometric method for fluoxetine (FLX) drug monitoring. The method is based on the integration of molecular imprinting polymer (MIP) beads as sensory elements with modified screen-printed solid contact ion-selective electrodes (ISEs). A multi-walled carbon nanotube (MWCNT) was used as a nanomaterial for the ion-to-electron transduction process. The prepared MIP beads depend on the use of acrylamide (AAm) and ethylene glycol dimethacrylic acid (EGDMA) as a functional monomer and cross-linker, respectively. The sensor revealed a stable response with a Nernstian slope of 58.9 ± 0.2 mV/decade and a detection limit of 2.1 × 10<sup>−6</sup> mol/L in 10 mmol/L acetate buffer of pH 4.5. The presented miniaturized sensors revealed good selectivity towards FLX over many organic and inorganic cations, as well as some additives encountered in the pharmaceutical preparations. Repeatability, reproducibility and stability have been studied to evaluate the analytical features of the presented sensors. These sensors were successfully applied for FLX assessment in different pharmaceutical formulations collected from the Egyptian local market. The obtained results agreed well with the acceptable recovery percentage and were better than those obtained by other previously reported routine methods.https://www.mdpi.com/2079-4991/10/3/572solid-contact isesmulti-walled carbon nanotubes (mwcnts)fluoxetinescreen-printed electrodesmethod validation |
spellingShingle | Saad S.M. Hassan Ayman H. Kamel Abd El-Galil E. Amr Heba M. Hashem E.M. Abdel Bary Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of Fluoxetine Nanomaterials solid-contact ises multi-walled carbon nanotubes (mwcnts) fluoxetine screen-printed electrodes method validation |
title | Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of Fluoxetine |
title_full | Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of Fluoxetine |
title_fullStr | Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of Fluoxetine |
title_full_unstemmed | Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of Fluoxetine |
title_short | Imprinted Polymeric Beads-Based Screen-Printed Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) for Selective Recognition of Fluoxetine |
title_sort | imprinted polymeric beads based screen printed potentiometric platforms modified with multi walled carbon nanotubes mwcnts for selective recognition of fluoxetine |
topic | solid-contact ises multi-walled carbon nanotubes (mwcnts) fluoxetine screen-printed electrodes method validation |
url | https://www.mdpi.com/2079-4991/10/3/572 |
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