Genetic Effects of Single Nucleotide Polymorphisms in the Goat <i>GDF9</i> Gene on Prolificacy: True or False Positive?
Goat reproductive traits are complex quantitative traits controlled by polygenes and multipoint. To date, some high-fertility candidate genes in livestock have been unearthed and the growth differentiation factor 9 (<i>GDF9</i>) gene is one of them, which plays a crucial role in early fo...
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| Format: | Article |
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MDPI AG
2019-10-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/9/11/886 |
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| author | Xinyu Wang Qing Yang Sihuan Zhang Xiaoyu Zhang Chuanying Pan Hong Chen Haijing Zhu Xianyong Lan |
| author_facet | Xinyu Wang Qing Yang Sihuan Zhang Xiaoyu Zhang Chuanying Pan Hong Chen Haijing Zhu Xianyong Lan |
| author_sort | Xinyu Wang |
| collection | DOAJ |
| description | Goat reproductive traits are complex quantitative traits controlled by polygenes and multipoint. To date, some high-fertility candidate genes in livestock have been unearthed and the growth differentiation factor 9 (<i>GDF9</i>) gene is one of them, which plays a crucial role in early folliculogenesis. According to the relevant previous studies and the National Center for Biotechnology Information Search database (NCBI), a total of 45 single nucleotide polymorphisms (SNPs) have been detected in the goat <i>GDF9</i> gene, but which one or which ones have important effects on goat fecundity is still uncertain. Hence, in order to find effective molecular markers for goat genetic breeding and accelerate the goat improvement, this study summarized and classified the above 45 SNPs into four kinds, as well as compared and analyzed the same SNP effects and the different SNPs linkage effects on the reproductive traits in different goat breeds. Since there were many SNPs in the goat <i>GDF9</i> gene, only 15 SNPs have been identified in more than 30 goat breeds worldwide and they showed different effects on the litter size. Therefore, this study mainly chose these 15 SNPs and discussed their relationship with goat productivity. Results showed that three non-synonymous SNPs A240V, Q320P, and V397I and three synonymous ones L61L, N121N, and L141L played a “true” role in the litter size trait in many goat breeds around the world. However, the regulatory mechanisms still need further research. These results provide an effective tool for follow-up research developing the goat molecular breeding strategies and improving the goat reproductive traits. |
| first_indexed | 2024-12-22T10:38:08Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-12-22T10:38:08Z |
| publishDate | 2019-10-01 |
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| series | Animals |
| spelling | doaj.art-7225add67f1e40d292aeb164fd3dc9a42022-12-21T18:29:07ZengMDPI AGAnimals2076-26152019-10-0191188610.3390/ani9110886ani9110886Genetic Effects of Single Nucleotide Polymorphisms in the Goat <i>GDF9</i> Gene on Prolificacy: True or False Positive?Xinyu Wang0Qing Yang1Sihuan Zhang2Xiaoyu Zhang3Chuanying Pan4Hong Chen5Haijing Zhu6Xianyong Lan7College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, ChinaCollege of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, ChinaShaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, ChinaCollege of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling 712100, ChinaGoat reproductive traits are complex quantitative traits controlled by polygenes and multipoint. To date, some high-fertility candidate genes in livestock have been unearthed and the growth differentiation factor 9 (<i>GDF9</i>) gene is one of them, which plays a crucial role in early folliculogenesis. According to the relevant previous studies and the National Center for Biotechnology Information Search database (NCBI), a total of 45 single nucleotide polymorphisms (SNPs) have been detected in the goat <i>GDF9</i> gene, but which one or which ones have important effects on goat fecundity is still uncertain. Hence, in order to find effective molecular markers for goat genetic breeding and accelerate the goat improvement, this study summarized and classified the above 45 SNPs into four kinds, as well as compared and analyzed the same SNP effects and the different SNPs linkage effects on the reproductive traits in different goat breeds. Since there were many SNPs in the goat <i>GDF9</i> gene, only 15 SNPs have been identified in more than 30 goat breeds worldwide and they showed different effects on the litter size. Therefore, this study mainly chose these 15 SNPs and discussed their relationship with goat productivity. Results showed that three non-synonymous SNPs A240V, Q320P, and V397I and three synonymous ones L61L, N121N, and L141L played a “true” role in the litter size trait in many goat breeds around the world. However, the regulatory mechanisms still need further research. These results provide an effective tool for follow-up research developing the goat molecular breeding strategies and improving the goat reproductive traits.https://www.mdpi.com/2076-2615/9/11/886goat<i>gdf9</i> genesnpreproductive traitsassociation |
| spellingShingle | Xinyu Wang Qing Yang Sihuan Zhang Xiaoyu Zhang Chuanying Pan Hong Chen Haijing Zhu Xianyong Lan Genetic Effects of Single Nucleotide Polymorphisms in the Goat <i>GDF9</i> Gene on Prolificacy: True or False Positive? Animals goat <i>gdf9</i> gene snp reproductive traits association |
| title | Genetic Effects of Single Nucleotide Polymorphisms in the Goat <i>GDF9</i> Gene on Prolificacy: True or False Positive? |
| title_full | Genetic Effects of Single Nucleotide Polymorphisms in the Goat <i>GDF9</i> Gene on Prolificacy: True or False Positive? |
| title_fullStr | Genetic Effects of Single Nucleotide Polymorphisms in the Goat <i>GDF9</i> Gene on Prolificacy: True or False Positive? |
| title_full_unstemmed | Genetic Effects of Single Nucleotide Polymorphisms in the Goat <i>GDF9</i> Gene on Prolificacy: True or False Positive? |
| title_short | Genetic Effects of Single Nucleotide Polymorphisms in the Goat <i>GDF9</i> Gene on Prolificacy: True or False Positive? |
| title_sort | genetic effects of single nucleotide polymorphisms in the goat i gdf9 i gene on prolificacy true or false positive |
| topic | goat <i>gdf9</i> gene snp reproductive traits association |
| url | https://www.mdpi.com/2076-2615/9/11/886 |
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