Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia
Background/Aim. Coronavirus disease 2019 (COVID-19) is a life-threatening disease characterized by a prothrombotic state. Because homocysteine (Hcy) is a potential biomarker in thrombotic disease, this article aims to highlight the role of Hcy in the prognosis of COVID-19 pneumonia. Methods. This pr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi-Wiley
2023-01-01
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| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/2023/9697871 |
| _version_ | 1797871862721544192 |
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| author | Işılay Kalan Sarı Olgun Keskin Ayşegül Seremet Keskin Hamit Yaşar Elli̇dağ Orbay Harmandar |
| author_facet | Işılay Kalan Sarı Olgun Keskin Ayşegül Seremet Keskin Hamit Yaşar Elli̇dağ Orbay Harmandar |
| author_sort | Işılay Kalan Sarı |
| collection | DOAJ |
| description | Background/Aim. Coronavirus disease 2019 (COVID-19) is a life-threatening disease characterized by a prothrombotic state. Because homocysteine (Hcy) is a potential biomarker in thrombotic disease, this article aims to highlight the role of Hcy in the prognosis of COVID-19 pneumonia. Methods. This prospective study was conducted between April 2021 and December 2021 at the University of Health Sciences, Antalya Training and Research Hospital. 162 patients admitted to the emergency department for COVID-19 pneumonia and scheduled for hospitalization in the intensive care unit (ICU) or COVID-19 ward of the chest disease department were included in the study. Hcy levels and other necessary laboratory parameters were analyzed. Results. 134 patients were admitted to the COVID-19 ward and 28 to the ICU. Hcy levels were significantly higher in ICU patients than in ward patients (p:0.001). Of the 134 patients, 55 later required ICU treatment for various reasons and were transferred to the ICU. Hcy (p:0.010), ferritin (p:0.041), and LDH (p:0.010) were significantly higher in patients who were transferred to the ICU than in patients who remained in the ward. The Hcy level was associated with a poor prognosis. It was found that each unit increase in the Hcy level approximately doubled the risk of death in patients with COVID-19 (odds ratio: 1.753). Discussion. There are few studies examining the association between high Hcy levels and disease severity in COVID-19. Our study supports previous studies and shows the association between the need for intensive care and high Hcy levels. Conclusion. A high Hcy value is a helpful marker in determining the need for critical care on admission to the emergency department and a marker of poor prognosis in COVID-19 pneumonia. |
| first_indexed | 2024-04-10T00:49:45Z |
| format | Article |
| id | doaj.art-7227f8495d3c4105b9c512c3c54fef10 |
| institution | Directory Open Access Journal |
| issn | 1742-1241 |
| language | English |
| last_indexed | 2024-04-10T00:49:45Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi-Wiley |
| record_format | Article |
| series | International Journal of Clinical Practice |
| spelling | doaj.art-7227f8495d3c4105b9c512c3c54fef102023-03-13T11:25:54ZengHindawi-WileyInternational Journal of Clinical Practice1742-12412023-01-01202310.1155/2023/9697871Is Homocysteine Associated with the Prognosis of Covid-19 PneumoniaIşılay Kalan Sarı0Olgun Keskin1Ayşegül Seremet Keskin2Hamit Yaşar Elli̇dağ3Orbay Harmandar4Department of Endocrinology and Metabolic DisordersDepartment of Chest DiseaseDepartment of Infectious Disease and Clinical MicrobiologyDepartment of Clinic of BiochemistryDepartment of Critical CareBackground/Aim. Coronavirus disease 2019 (COVID-19) is a life-threatening disease characterized by a prothrombotic state. Because homocysteine (Hcy) is a potential biomarker in thrombotic disease, this article aims to highlight the role of Hcy in the prognosis of COVID-19 pneumonia. Methods. This prospective study was conducted between April 2021 and December 2021 at the University of Health Sciences, Antalya Training and Research Hospital. 162 patients admitted to the emergency department for COVID-19 pneumonia and scheduled for hospitalization in the intensive care unit (ICU) or COVID-19 ward of the chest disease department were included in the study. Hcy levels and other necessary laboratory parameters were analyzed. Results. 134 patients were admitted to the COVID-19 ward and 28 to the ICU. Hcy levels were significantly higher in ICU patients than in ward patients (p:0.001). Of the 134 patients, 55 later required ICU treatment for various reasons and were transferred to the ICU. Hcy (p:0.010), ferritin (p:0.041), and LDH (p:0.010) were significantly higher in patients who were transferred to the ICU than in patients who remained in the ward. The Hcy level was associated with a poor prognosis. It was found that each unit increase in the Hcy level approximately doubled the risk of death in patients with COVID-19 (odds ratio: 1.753). Discussion. There are few studies examining the association between high Hcy levels and disease severity in COVID-19. Our study supports previous studies and shows the association between the need for intensive care and high Hcy levels. Conclusion. A high Hcy value is a helpful marker in determining the need for critical care on admission to the emergency department and a marker of poor prognosis in COVID-19 pneumonia.http://dx.doi.org/10.1155/2023/9697871 |
| spellingShingle | Işılay Kalan Sarı Olgun Keskin Ayşegül Seremet Keskin Hamit Yaşar Elli̇dağ Orbay Harmandar Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia International Journal of Clinical Practice |
| title | Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia |
| title_full | Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia |
| title_fullStr | Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia |
| title_full_unstemmed | Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia |
| title_short | Is Homocysteine Associated with the Prognosis of Covid-19 Pneumonia |
| title_sort | is homocysteine associated with the prognosis of covid 19 pneumonia |
| url | http://dx.doi.org/10.1155/2023/9697871 |
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