THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
It is reported that the implementation in clinical practice thrombolytic (fibrinolytic) therapy resulted inmortality reduction during firstmonth after myocardial infarction from 17-18% to 5-8%. Different details of this therapy are considered: terms of thrombolysis since the beginning of myocardial...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2016-01-01
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| Series: | Рациональная фармакотерапия в кардиологии |
| Subjects: | |
| Online Access: | https://www.rpcardio.online/jour/article/view/1054 |
| _version_ | 1797232298754572288 |
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| author | E. V. Konstantinova A. V. Magnitskyi N. A. Schostak |
| author_facet | E. V. Konstantinova A. V. Magnitskyi N. A. Schostak |
| author_sort | E. V. Konstantinova |
| collection | DOAJ |
| description | It is reported that the implementation in clinical practice thrombolytic (fibrinolytic) therapy resulted inmortality reduction during firstmonth after myocardial infarction from 17-18% to 5-8%. Different details of this therapy are considered: terms of thrombolysis since the beginning of myocardial infarction, alternative methods of coronary blood flow recovery , indications and contraindications, complications and side effects, estimation of thrombolysis efficacy. Fibrin-selective and fibrin-non-selective drugs are presented. Different fibrinolytics are described: streptokinase, anistreplase, alteplase, reteplase, tenekteplase. The results of large randomized clinical trials devoted to fibrinolytic therapy of myocardial infarction are analyzed: GISSI, ISSIS, TIMI, GUSTO, INJECT, ASSENT. The possibility to increase in efficacy and safety of fibrinolytics by their combination with acetylsalicylic acid, IIb/IIIa receptor inhibitors and heparins are discussed. |
| first_indexed | 2024-03-08T14:03:07Z |
| format | Article |
| id | doaj.art-722abf6c62434e788706c131eac1b3f8 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-04-24T15:58:03Z |
| publishDate | 2016-01-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-722abf6c62434e788706c131eac1b3f82024-04-01T07:43:31ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532016-01-0124586210.20996/1819-6446-2006-2-4-58-621053THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTIONE. V. Konstantinova0A. V. Magnitskyi1N. A. Schostak2Russian state medical University of RoszdravRussian state medical University of RoszdravRussian state medical University of RoszdravIt is reported that the implementation in clinical practice thrombolytic (fibrinolytic) therapy resulted inmortality reduction during firstmonth after myocardial infarction from 17-18% to 5-8%. Different details of this therapy are considered: terms of thrombolysis since the beginning of myocardial infarction, alternative methods of coronary blood flow recovery , indications and contraindications, complications and side effects, estimation of thrombolysis efficacy. Fibrin-selective and fibrin-non-selective drugs are presented. Different fibrinolytics are described: streptokinase, anistreplase, alteplase, reteplase, tenekteplase. The results of large randomized clinical trials devoted to fibrinolytic therapy of myocardial infarction are analyzed: GISSI, ISSIS, TIMI, GUSTO, INJECT, ASSENT. The possibility to increase in efficacy and safety of fibrinolytics by their combination with acetylsalicylic acid, IIb/IIIa receptor inhibitors and heparins are discussed.https://www.rpcardio.online/jour/article/view/1054myocardial infarctionthrombolysisfibrinolyticsstreptokinaseanistreplasealteplasereteplasetenekteplase |
| spellingShingle | E. V. Konstantinova A. V. Magnitskyi N. A. Schostak THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Рациональная фармакотерапия в кардиологии myocardial infarction thrombolysis fibrinolytics streptokinase anistreplase alteplase reteplase tenekteplase |
| title | THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_full | THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_fullStr | THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_full_unstemmed | THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_short | THROMBOLYTIC THERAPY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION |
| title_sort | thrombolytic therapy in patients with acute myocardial infarction |
| topic | myocardial infarction thrombolysis fibrinolytics streptokinase anistreplase alteplase reteplase tenekteplase |
| url | https://www.rpcardio.online/jour/article/view/1054 |
| work_keys_str_mv | AT evkonstantinova thrombolytictherapyinpatientswithacutemyocardialinfarction AT avmagnitskyi thrombolytictherapyinpatientswithacutemyocardialinfarction AT naschostak thrombolytictherapyinpatientswithacutemyocardialinfarction |