ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion
Salma M S Ahmad, Hanan Nazar, Md Mizanur Rahman, Radoslaw Stefan Rusyniak, Allal Ouhtit Biological Sciences Program, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha, QatarCorrespondence: Allal Ouhtit, Department of Biological and Environmental...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-05-01
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| Series: | Breast Cancer: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/itgb1bp1-a-novel-transcriptional-target-of-cd44-downstream-signaling-p-peer-reviewed-fulltext-article-BCTT |
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| author | Ahmad SMS Nazar H Rahman MM Rusyniak RS Ouhtit A |
| author_facet | Ahmad SMS Nazar H Rahman MM Rusyniak RS Ouhtit A |
| author_sort | Ahmad SMS |
| collection | DOAJ |
| description | Salma M S Ahmad, Hanan Nazar, Md Mizanur Rahman, Radoslaw Stefan Rusyniak, Allal Ouhtit Biological Sciences Program, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha, QatarCorrespondence: Allal Ouhtit, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, PO Box 2713, Doha, Qatar, Tel +974 4403-7572, Email aouhtit@qu.edu.qaAbstract: Breast cancer (BC) is the most common malignancy worldwide and has a poor prognosis, because it begins in the breast and disseminates to lymph nodes and distant organs. While invading, BC cells acquire aggressive characteristics from the tumor microenvironment through several mechanisms. Thus, understanding the mechanisms underlying the process of BC cell invasion can pave the way towards the development of targeted therapeutics focused on metastasis. We have previously reported that the activation of CD44 receptor with its major ligand hyaluronan (HA) promotes BC metastasis to the liver in vivo. Next, a gene expression profiling microarray analysis was conducted to identify and validate CD44-downstream transcriptional targets mediating its pro-metastatic function from RNA samples collected from Tet CD44-induced versus control MCF7-B5 cells. We have already validated a number of novel CD44-target genes and published their underlying signaling pathways in promoting BC cell invasion. From the same microarray analysis, Integrin subunit beta 1 binding protein 1 (ITGB1BP1) was also identified as a potential CD44-target gene that was upregulated (2-fold) upon HA activation of CD44. This report will review the lines of evidence collected from the literature to support our hypothesis, and further discuss the possible mechanisms linking HA activation of CD44 to its novel potential transcriptional target ITGB1BP1.Keywords: ITGB1BP1, Breast cancer, CD44, Hyaluronan, metastasis |
| first_indexed | 2024-03-13T09:33:26Z |
| format | Article |
| id | doaj.art-722bf30ee43e4267bb7520654c177b2c |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-03-13T09:33:26Z |
| publishDate | 2023-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-722bf30ee43e4267bb7520654c177b2c2023-05-25T18:06:00ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142023-05-01Volume 1537338083942ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell InvasionAhmad SMSNazar HRahman MMRusyniak RSOuhtit ASalma M S Ahmad, Hanan Nazar, Md Mizanur Rahman, Radoslaw Stefan Rusyniak, Allal Ouhtit Biological Sciences Program, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha, QatarCorrespondence: Allal Ouhtit, Department of Biological and Environmental Sciences, College of Arts and Science, Qatar University, PO Box 2713, Doha, Qatar, Tel +974 4403-7572, Email aouhtit@qu.edu.qaAbstract: Breast cancer (BC) is the most common malignancy worldwide and has a poor prognosis, because it begins in the breast and disseminates to lymph nodes and distant organs. While invading, BC cells acquire aggressive characteristics from the tumor microenvironment through several mechanisms. Thus, understanding the mechanisms underlying the process of BC cell invasion can pave the way towards the development of targeted therapeutics focused on metastasis. We have previously reported that the activation of CD44 receptor with its major ligand hyaluronan (HA) promotes BC metastasis to the liver in vivo. Next, a gene expression profiling microarray analysis was conducted to identify and validate CD44-downstream transcriptional targets mediating its pro-metastatic function from RNA samples collected from Tet CD44-induced versus control MCF7-B5 cells. We have already validated a number of novel CD44-target genes and published their underlying signaling pathways in promoting BC cell invasion. From the same microarray analysis, Integrin subunit beta 1 binding protein 1 (ITGB1BP1) was also identified as a potential CD44-target gene that was upregulated (2-fold) upon HA activation of CD44. This report will review the lines of evidence collected from the literature to support our hypothesis, and further discuss the possible mechanisms linking HA activation of CD44 to its novel potential transcriptional target ITGB1BP1.Keywords: ITGB1BP1, Breast cancer, CD44, Hyaluronan, metastasishttps://www.dovepress.com/itgb1bp1-a-novel-transcriptional-target-of-cd44-downstream-signaling-p-peer-reviewed-fulltext-article-BCTTitgb1bp1breast cancercd44hyaluronanmetastasis |
| spellingShingle | Ahmad SMS Nazar H Rahman MM Rusyniak RS Ouhtit A ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion Breast Cancer: Targets and Therapy itgb1bp1 breast cancer cd44 hyaluronan metastasis |
| title | ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion |
| title_full | ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion |
| title_fullStr | ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion |
| title_full_unstemmed | ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion |
| title_short | ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion |
| title_sort | itgb1bp1 a novel transcriptional target of cd44 downstream signaling promoting cancer cell invasion |
| topic | itgb1bp1 breast cancer cd44 hyaluronan metastasis |
| url | https://www.dovepress.com/itgb1bp1-a-novel-transcriptional-target-of-cd44-downstream-signaling-p-peer-reviewed-fulltext-article-BCTT |
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