Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors utilize DNA methylation based subgroups in JMML to predict clinical outcome.
Main Authors: | Elliot Stieglitz, Tali Mazor, Adam B. Olshen, Huimin Geng, Laura C. Gelston, Jon Akutagawa, Daniel B. Lipka, Christoph Plass, Christian Flotho, Farid F. Chehab, Benjamin S. Braun, Joseph F. Costello, Mignon L. Loh |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2017-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-02178-9 |
Similar Items
-
Molecular and phenotypic diversity of <I>CBL</I>-mutated juvenile myelomonocytic leukemia
by: Anna Hecht, et al.
Published: (2020-12-01) -
Gene mutations do not operate in a vacuum: the increasing importance of epigenetics in juvenile myelomonocytic leukemia
by: Christian Flotho
Published: (2019-03-01) -
Juvenile myelomonocytic leukemia: Molecular pathogenesis informs current approaches to therapy & hematopoietic cell transplantation
by: Mignon Lee-cheun Loh, et al.
Published: (2014-03-01) -
THE INTERFACE OF EPIGENETICS AND ENERGY METABOLISM IN JUVENILE MYELOMONOCYTIC LEUKEMIA
by: Zoé Wehbe, et al.
Published: (2023-12-01) -
Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia
by: Silvia Fluhr, et al.
Published: (2017-08-01)