Macrophage‐derived extracellular vesicles regulate follicular activation and improve ovarian function in old mice by modulating local environment

Macrophage‐derived extracellular vesicles regulate follicular activation and improve ovarian function in old mice by modulating local environment

Abstract In mammals, ovarian function is dependent on the primordial follicle pool and the rate of primordial follicle activation determines a female's reproductive lifespan. Ovarian ageing is characterised by chronic low‐grade inflammation with accelerated depletion of primordial follicles and...

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Bibliographic Details
Main Authors: Yue Xiao, Xiaoxu Peng, Yue Peng, Chi Zhang, Wei Liu, Weijie Yang, Xiaowei Dou, Yuying Jiang, Yaxuan Wang, Shuo Yang, Wenpei Xiang, Tinghe Wu, Jing Li
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Clinical and Translational Medicine
Subjects:
extracellular vesicles
macrophage
ovarian ageing
primordial follicle
Online Access:https://doi.org/10.1002/ctm2.1071

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