Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation
Aim of this retrospective study was to estimate the effect of oral supplementation with amino acids (AA) on corneal nerves regrowth after excimer laser refractive surgery with photorefractive keratectomy (PRK). Based on the pre and post-surgical treatment received, 40 patients with 12 months of foll...
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.680734/full |
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| author | Anna M Roszkowska Dario Rusciano Leandro Inferrera Alice Antonella Severo Pasquale Aragona |
| author_facet | Anna M Roszkowska Dario Rusciano Leandro Inferrera Alice Antonella Severo Pasquale Aragona |
| author_sort | Anna M Roszkowska |
| collection | DOAJ |
| description | Aim of this retrospective study was to estimate the effect of oral supplementation with amino acids (AA) on corneal nerves regrowth after excimer laser refractive surgery with photorefractive keratectomy (PRK). Based on the pre and post-surgical treatment received, 40 patients with 12 months of follow-up were distributed in two groups: 20 patients had received oral AA supplementation 7 days before and 30 days after PRK, and 20 patients without AA supplementation, as untreated reference control. All patients followed the same standard post-operative topical therapy consisting of an association of antibiotic and steroid plus sodium hyaluronate during the first week, then steroid alone progressively decreasing during 30 days and sodium hyaluronate for the following 3 months. In vivo corneal confocal microscopy was used to evaluate the presence of sub-basal corneal nerve fibers during 12 months after PRK. Results have shown that sub-basal nerves regenerated significantly faster (p <0.05), and nerve fibers density was significantly higher (p <0.05) with a more regular pattern in the eyes of AA treated patients with respect to the untreated control group. Therefore, our data indicate that oral supplementation with AA improved significantly corneal nerve restoration after PRK and could thus be considered as an additional treatment during corneal surgical procedures. |
| first_indexed | 2024-12-16T23:06:06Z |
| format | Article |
| id | doaj.art-7232361231994021b42e81368f0ab609 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-16T23:06:06Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7232361231994021b42e81368f0ab6092022-12-21T22:12:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-07-011210.3389/fphar.2021.680734680734Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based InvestigationAnna M Roszkowska0Dario Rusciano1Leandro Inferrera2Alice Antonella Severo3Pasquale Aragona4Ophthalmology Clinic, Department of Biomedical Sciences, University of Messina, Messina, ItalySooft Italia SpA Research Center, Catania, ItalyOphthalmology Clinic, Department of Biomedical Sciences, University of Messina, Messina, ItalyOphthalmology Clinic, Department of Biomedical Sciences, University of Messina, Messina, ItalyOphthalmology Clinic, Department of Biomedical Sciences, University of Messina, Messina, ItalyAim of this retrospective study was to estimate the effect of oral supplementation with amino acids (AA) on corneal nerves regrowth after excimer laser refractive surgery with photorefractive keratectomy (PRK). Based on the pre and post-surgical treatment received, 40 patients with 12 months of follow-up were distributed in two groups: 20 patients had received oral AA supplementation 7 days before and 30 days after PRK, and 20 patients without AA supplementation, as untreated reference control. All patients followed the same standard post-operative topical therapy consisting of an association of antibiotic and steroid plus sodium hyaluronate during the first week, then steroid alone progressively decreasing during 30 days and sodium hyaluronate for the following 3 months. In vivo corneal confocal microscopy was used to evaluate the presence of sub-basal corneal nerve fibers during 12 months after PRK. Results have shown that sub-basal nerves regenerated significantly faster (p <0.05), and nerve fibers density was significantly higher (p <0.05) with a more regular pattern in the eyes of AA treated patients with respect to the untreated control group. Therefore, our data indicate that oral supplementation with AA improved significantly corneal nerve restoration after PRK and could thus be considered as an additional treatment during corneal surgical procedures.https://www.frontiersin.org/articles/10.3389/fphar.2021.680734/fullaminoacidsPRKcorneacorneal nervesnerve growthconfocal microscopy |
| spellingShingle | Anna M Roszkowska Dario Rusciano Leandro Inferrera Alice Antonella Severo Pasquale Aragona Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation Frontiers in Pharmacology aminoacids PRK cornea corneal nerves nerve growth confocal microscopy |
| title | Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation |
| title_full | Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation |
| title_fullStr | Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation |
| title_full_unstemmed | Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation |
| title_short | Oral Aminoacids Supplementation Improves Corneal Reinnervation After Photorefractive Keratectomy: A Confocal-Based Investigation |
| title_sort | oral aminoacids supplementation improves corneal reinnervation after photorefractive keratectomy a confocal based investigation |
| topic | aminoacids PRK cornea corneal nerves nerve growth confocal microscopy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.680734/full |
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