Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma—A 15-Year Retrospective Single-Center Study
Tian Zhi, Weiling Zhang, Yi Zhang, Huimin Hu, Dongsheng Huang Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, 100176, People’s Republic of ChinaCorrespondence: Dongsheng HuangDepartment of Pediatrics, Beijing Tongren Hospital, Capital Medical Univer...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-04-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/clinical-characteristics-and-prognosis-analysis-of-infantile-hepatobla-peer-reviewed-article-CMAR |
| _version_ | 1818430511212658688 |
|---|---|
| author | Zhi T Zhang W Zhang Y Hu H Huang D |
| author_facet | Zhi T Zhang W Zhang Y Hu H Huang D |
| author_sort | Zhi T |
| collection | DOAJ |
| description | Tian Zhi, Weiling Zhang, Yi Zhang, Huimin Hu, Dongsheng Huang Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, 100176, People’s Republic of ChinaCorrespondence: Dongsheng HuangDepartment of Pediatrics, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Dongcheng District, Beijing, 100730, People’s Republic of ChinaTel/Fax +86 10 58266032Email huamgdomgshemg@163.comObjective: The present study aimed to summarize the clinical data of hepatoblastoma (HB) in infants under one year of age and to analyze the factors that affected the prognoses.Methods: The clinical data of 132 pediatric patients with a pathologically confirmed HB, aged less than one year and who had visited the Pediatric Single Center of Beijing Tongren Hospital from May 2005 to May 2019, were retrospectively analyzed to summarize the clinical outcomes and prognoses.Results: The male/female ratio was 1.27 and the median age was 8.40 months. The onset of HB was usually characterized by abdominal bulging (75.0%). The median level of AFP at the first visit was 154.7μg/mL, and the average platelet count was (405± 166)× 109/L. The epithelial type (57.6%) was the predominant pathological type, and stage III (54.5%) was the main PRETEXT staging. Distant metastases occurred in 45 cases, with pulmonary metastases (86.7%) being the most common site. At the time of visit, 24 cases (18.2%) had either portal vein, hepatic vein, or vena cava infiltration. Five cases (3.8%) had a hemorrhage of the ruptured tumor, and 26 cases (19.7%) had multiple intrahepatic foci. At the follow-up in May 2020, the overall survival (OS) rate at one, three, and five years of age was 94.3%, 88.8%, and 80.1%, respectively, and the event-free survival rate was 91.8%, 86.9%, and 77.5%, respectively, by the Kaplan–Meier survival analysis. According to the Log rank test, pediatric patients with an AFP < 100ng/mL, a PRETEXT stage IV, presence of distant metastases and multiple foci of the primary tumor at the initial diagnosis had poorer prognoses (P< 0.05).Conclusion: The prognosis of HB in infancy is relatively good, but is still vulnerable to multiple factors, such as tumor features leading to different AFP levels, PRETEXT stage, presence of distant metastases, and multiple intrahepatic foci.Keywords: hepatoblastoma, infant, AFP, chemotherapy, prognosis |
| first_indexed | 2024-12-14T15:34:34Z |
| format | Article |
| id | doaj.art-723280848dc547158b34e1b4f0528c7b |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-14T15:34:34Z |
| publishDate | 2021-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-723280848dc547158b34e1b4f0528c7b2022-12-21T22:55:45ZengDove Medical PressCancer Management and Research1179-13222021-04-01Volume 133201320863850Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma—A 15-Year Retrospective Single-Center StudyZhi TZhang WZhang YHu HHuang DTian Zhi, Weiling Zhang, Yi Zhang, Huimin Hu, Dongsheng Huang Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, 100176, People’s Republic of ChinaCorrespondence: Dongsheng HuangDepartment of Pediatrics, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaominxiang Dongcheng District, Beijing, 100730, People’s Republic of ChinaTel/Fax +86 10 58266032Email huamgdomgshemg@163.comObjective: The present study aimed to summarize the clinical data of hepatoblastoma (HB) in infants under one year of age and to analyze the factors that affected the prognoses.Methods: The clinical data of 132 pediatric patients with a pathologically confirmed HB, aged less than one year and who had visited the Pediatric Single Center of Beijing Tongren Hospital from May 2005 to May 2019, were retrospectively analyzed to summarize the clinical outcomes and prognoses.Results: The male/female ratio was 1.27 and the median age was 8.40 months. The onset of HB was usually characterized by abdominal bulging (75.0%). The median level of AFP at the first visit was 154.7μg/mL, and the average platelet count was (405± 166)× 109/L. The epithelial type (57.6%) was the predominant pathological type, and stage III (54.5%) was the main PRETEXT staging. Distant metastases occurred in 45 cases, with pulmonary metastases (86.7%) being the most common site. At the time of visit, 24 cases (18.2%) had either portal vein, hepatic vein, or vena cava infiltration. Five cases (3.8%) had a hemorrhage of the ruptured tumor, and 26 cases (19.7%) had multiple intrahepatic foci. At the follow-up in May 2020, the overall survival (OS) rate at one, three, and five years of age was 94.3%, 88.8%, and 80.1%, respectively, and the event-free survival rate was 91.8%, 86.9%, and 77.5%, respectively, by the Kaplan–Meier survival analysis. According to the Log rank test, pediatric patients with an AFP < 100ng/mL, a PRETEXT stage IV, presence of distant metastases and multiple foci of the primary tumor at the initial diagnosis had poorer prognoses (P< 0.05).Conclusion: The prognosis of HB in infancy is relatively good, but is still vulnerable to multiple factors, such as tumor features leading to different AFP levels, PRETEXT stage, presence of distant metastases, and multiple intrahepatic foci.Keywords: hepatoblastoma, infant, AFP, chemotherapy, prognosishttps://www.dovepress.com/clinical-characteristics-and-prognosis-analysis-of-infantile-hepatobla-peer-reviewed-article-CMARhepatoblastomainfantafpchemotherapyprognosis |
| spellingShingle | Zhi T Zhang W Zhang Y Hu H Huang D Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma—A 15-Year Retrospective Single-Center Study Cancer Management and Research hepatoblastoma infant afp chemotherapy prognosis |
| title | Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma—A 15-Year Retrospective Single-Center Study |
| title_full | Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma—A 15-Year Retrospective Single-Center Study |
| title_fullStr | Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma—A 15-Year Retrospective Single-Center Study |
| title_full_unstemmed | Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma—A 15-Year Retrospective Single-Center Study |
| title_short | Clinical Characteristics and Prognosis Analysis of Infantile Hepatoblastoma—A 15-Year Retrospective Single-Center Study |
| title_sort | clinical characteristics and prognosis analysis of infantile hepatoblastoma mdash a 15 year retrospective single center study |
| topic | hepatoblastoma infant afp chemotherapy prognosis |
| url | https://www.dovepress.com/clinical-characteristics-and-prognosis-analysis-of-infantile-hepatobla-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT zhit clinicalcharacteristicsandprognosisanalysisofinfantilehepatoblastomamdasha15yearretrospectivesinglecenterstudy AT zhangw clinicalcharacteristicsandprognosisanalysisofinfantilehepatoblastomamdasha15yearretrospectivesinglecenterstudy AT zhangy clinicalcharacteristicsandprognosisanalysisofinfantilehepatoblastomamdasha15yearretrospectivesinglecenterstudy AT huh clinicalcharacteristicsandprognosisanalysisofinfantilehepatoblastomamdasha15yearretrospectivesinglecenterstudy AT huangd clinicalcharacteristicsandprognosisanalysisofinfantilehepatoblastomamdasha15yearretrospectivesinglecenterstudy |