The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin
Doxorubicin (DOX) is an anthracycline antibiotic used for anticancer therapy. However, this agent can cause various systemic side effects including cognitive impairments in chronic use. Brain damage due to DOX is caused by an increase of tumor necrosis factor-alpha (TNF-α) level in the brain. Increa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Bogor Agricultural University
2016-04-01
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| Series: | Hayati Journal of Biosciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1978301915300309 |
| _version_ | 1818430269860872192 |
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| author | Soni Siswanto Wawaimuli Arozal Vetnizah Juniantito Agatha Grace Femmi Dwinda Agustini Nafrialdi |
| author_facet | Soni Siswanto Wawaimuli Arozal Vetnizah Juniantito Agatha Grace Femmi Dwinda Agustini Nafrialdi |
| author_sort | Soni Siswanto |
| collection | DOAJ |
| description | Doxorubicin (DOX) is an anthracycline antibiotic used for anticancer therapy. However, this agent can cause various systemic side effects including cognitive impairments in chronic use. Brain damage due to DOX is caused by an increase of tumor necrosis factor-alpha (TNF-α) level in the brain. Increased TNF-α can further lead to chronic inflammation which can lead to neuronal deaths or neurodegenerative diseases. Mangiferin (MAG), a compound extracted from Mangifera indica, has been found neuroprotective activities, but its effect on DOX-induced brain damage is unknown. This study aims to determine the effect of MAG on brain damage induced by DOX. Male Sprague-Dawley rats were induced by DOX intraperitoneally. MAG was given orally at the doses of 30 and 60 mg/kg bw for 7 consecutive weeks. The parameters measured were inflammatory and oxidative stress markers in brain tissue. Coadministration of MAG with DOX reduced inflammation which was marked by the reduction of TNF-α mRNA expression, decreased TNF-α level and reduction of oxidative stress marked by increase of superoxide dismutase level and decrease of malondialdehyde level. In conclusion, MAG was shown to have a neuroprotective effect on brain damage induced by DOX, partly due to inhibition of inflammation and oxidative stress. |
| first_indexed | 2024-12-14T15:30:44Z |
| format | Article |
| id | doaj.art-7232e97f009d4d278dfa6c1a47637acb |
| institution | Directory Open Access Journal |
| issn | 1978-3019 |
| language | English |
| last_indexed | 2024-12-14T15:30:44Z |
| publishDate | 2016-04-01 |
| publisher | Bogor Agricultural University |
| record_format | Article |
| series | Hayati Journal of Biosciences |
| spelling | doaj.art-7232e97f009d4d278dfa6c1a47637acb2022-12-21T22:55:53ZengBogor Agricultural UniversityHayati Journal of Biosciences1978-30192016-04-01232515510.1016/j.hjb.2016.02.001The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by DoxorubicinSoni Siswanto0Wawaimuli Arozal1Vetnizah Juniantito2Agatha Grace3Femmi Dwinda Agustini4Nafrialdi5Biomedical Science Program, Faculty of Medicine, Universitas Indonesia, Central Jakarta, IndonesiaDepartment of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Central Jakarta, IndonesiaDepartment of Clinic, Reproduction and Pathology, Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, IndonesiaBiomedical Science Program, Faculty of Medicine, Universitas Indonesia, Central Jakarta, IndonesiaBiomedical Science Program, Faculty of Medicine, Universitas Indonesia, Central Jakarta, IndonesiaBiomedical Science Program, Faculty of Medicine, Universitas Indonesia, Central Jakarta, IndonesiaDoxorubicin (DOX) is an anthracycline antibiotic used for anticancer therapy. However, this agent can cause various systemic side effects including cognitive impairments in chronic use. Brain damage due to DOX is caused by an increase of tumor necrosis factor-alpha (TNF-α) level in the brain. Increased TNF-α can further lead to chronic inflammation which can lead to neuronal deaths or neurodegenerative diseases. Mangiferin (MAG), a compound extracted from Mangifera indica, has been found neuroprotective activities, but its effect on DOX-induced brain damage is unknown. This study aims to determine the effect of MAG on brain damage induced by DOX. Male Sprague-Dawley rats were induced by DOX intraperitoneally. MAG was given orally at the doses of 30 and 60 mg/kg bw for 7 consecutive weeks. The parameters measured were inflammatory and oxidative stress markers in brain tissue. Coadministration of MAG with DOX reduced inflammation which was marked by the reduction of TNF-α mRNA expression, decreased TNF-α level and reduction of oxidative stress marked by increase of superoxide dismutase level and decrease of malondialdehyde level. In conclusion, MAG was shown to have a neuroprotective effect on brain damage induced by DOX, partly due to inhibition of inflammation and oxidative stress.http://www.sciencedirect.com/science/article/pii/S1978301915300309braindoxorubicininflammationmangiferinoxidative stress |
| spellingShingle | Soni Siswanto Wawaimuli Arozal Vetnizah Juniantito Agatha Grace Femmi Dwinda Agustini Nafrialdi The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin Hayati Journal of Biosciences brain doxorubicin inflammation mangiferin oxidative stress |
| title | The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin |
| title_full | The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin |
| title_fullStr | The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin |
| title_full_unstemmed | The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin |
| title_short | The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin |
| title_sort | effect of mangiferin against brain damage caused by oxidative stress and inflammation induced by doxorubicin |
| topic | brain doxorubicin inflammation mangiferin oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S1978301915300309 |
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