Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis
Abstract Background Myosteatosis has been reported to be a novel biomarker that could predict survival outcomes in patients with colorectal cancer. However, results have been conflicting. This systematic review and meta‐analysis aimed to evaluate the long‐term impact of myosteatosis on the survival...
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| Format: | Article |
| Language: | English |
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Wiley
2020-10-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
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| Online Access: | https://doi.org/10.1002/jcsm.12575 |
| _version_ | 1797205294620606464 |
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| author | Chan Mi Lee Jeonghyun Kang |
| author_facet | Chan Mi Lee Jeonghyun Kang |
| author_sort | Chan Mi Lee |
| collection | DOAJ |
| description | Abstract Background Myosteatosis has been reported to be a novel biomarker that could predict survival outcomes in patients with colorectal cancer. However, results have been conflicting. This systematic review and meta‐analysis aimed to evaluate the long‐term impact of myosteatosis on the survival of these patients. Methods A systematic search of PubMed, Embase, and Cochrane up to 27 November 2019 generated 7022 records. Studies that reported hazard ratio (HR) for overall survival, cancer‐specific survival, or disease‐free survival based on myosteatosis or radiodensity were included. A total of 110 full‐text articles were considered for inclusion, and 14 were selected for qualitative analysis. Inverse variance method was used with random effects model for data analysis. Results The total number of enrolled patients included in the meta‐analysis was 6518 for univariate and 8572 for multivariate HR analysis, from 12 and 10 studies, respectively. Patients with myosteatosis had a significant increase in overall mortality compared with non‐myosteatosis patients by both univariate analysis [HR 1.38, 95% confidence interval (CI) 1.21 to 1.58, P < 0.00001] and multivariate analysis (HR 1.55, 95% CI 1.23 to 1.96, P < 0.00001). In subgroup analysis based on studies that reported HRs of both sarcopenia and myosteatosis, the negative effect of myosteatosis on overall survival was independent of sarcopenia using univariate values (sarcopenia HR 1.48, 95% CI 1.14 to 1.91, P = 0.003 vs. myosteatosis HR 1.51, 95% CI 1.17 to 1.96, P = 0.002) and multivariate values (sarcopenia HR 1.28, 95% CI 1.09 to 1.49, P = 0.002 vs. myosteatosis HR 1.38, 95% CI 1.07 to 1.80, P = 0.001). Conclusions This meta‐analysis demonstrates that myosteatosis is associated with worse overall survival in patients with colorectal cancer. More investigation is needed to standardize the measurement protocol for myosteatosis and to further optimize its prognostic power for colorectal cancer patients. |
| first_indexed | 2024-04-24T08:48:50Z |
| format | Article |
| id | doaj.art-7233188b777d426890152f28f49317db |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-24T08:48:50Z |
| publishDate | 2020-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-7233188b777d426890152f28f49317db2024-04-16T12:37:19ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092020-10-011151270128210.1002/jcsm.12575Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysisChan Mi Lee0Jeonghyun Kang1Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Cleveland OH USADepartment of Surgery Gangnam Severance Hospital, Yonsei University College of Medicine Gangnam‐gu Seoul KoreaAbstract Background Myosteatosis has been reported to be a novel biomarker that could predict survival outcomes in patients with colorectal cancer. However, results have been conflicting. This systematic review and meta‐analysis aimed to evaluate the long‐term impact of myosteatosis on the survival of these patients. Methods A systematic search of PubMed, Embase, and Cochrane up to 27 November 2019 generated 7022 records. Studies that reported hazard ratio (HR) for overall survival, cancer‐specific survival, or disease‐free survival based on myosteatosis or radiodensity were included. A total of 110 full‐text articles were considered for inclusion, and 14 were selected for qualitative analysis. Inverse variance method was used with random effects model for data analysis. Results The total number of enrolled patients included in the meta‐analysis was 6518 for univariate and 8572 for multivariate HR analysis, from 12 and 10 studies, respectively. Patients with myosteatosis had a significant increase in overall mortality compared with non‐myosteatosis patients by both univariate analysis [HR 1.38, 95% confidence interval (CI) 1.21 to 1.58, P < 0.00001] and multivariate analysis (HR 1.55, 95% CI 1.23 to 1.96, P < 0.00001). In subgroup analysis based on studies that reported HRs of both sarcopenia and myosteatosis, the negative effect of myosteatosis on overall survival was independent of sarcopenia using univariate values (sarcopenia HR 1.48, 95% CI 1.14 to 1.91, P = 0.003 vs. myosteatosis HR 1.51, 95% CI 1.17 to 1.96, P = 0.002) and multivariate values (sarcopenia HR 1.28, 95% CI 1.09 to 1.49, P = 0.002 vs. myosteatosis HR 1.38, 95% CI 1.07 to 1.80, P = 0.001). Conclusions This meta‐analysis demonstrates that myosteatosis is associated with worse overall survival in patients with colorectal cancer. More investigation is needed to standardize the measurement protocol for myosteatosis and to further optimize its prognostic power for colorectal cancer patients.https://doi.org/10.1002/jcsm.12575MyosteatosisSkeletal muscle densitySurvivalColorectal cancer |
| spellingShingle | Chan Mi Lee Jeonghyun Kang Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis Journal of Cachexia, Sarcopenia and Muscle Myosteatosis Skeletal muscle density Survival Colorectal cancer |
| title | Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis |
| title_full | Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis |
| title_fullStr | Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis |
| title_full_unstemmed | Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis |
| title_short | Prognostic impact of myosteatosis in patients with colorectal cancer: a systematic review and meta‐analysis |
| title_sort | prognostic impact of myosteatosis in patients with colorectal cancer a systematic review and meta analysis |
| topic | Myosteatosis Skeletal muscle density Survival Colorectal cancer |
| url | https://doi.org/10.1002/jcsm.12575 |
| work_keys_str_mv | AT chanmilee prognosticimpactofmyosteatosisinpatientswithcolorectalcancerasystematicreviewandmetaanalysis AT jeonghyunkang prognosticimpactofmyosteatosisinpatientswithcolorectalcancerasystematicreviewandmetaanalysis |