Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats

Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats

Left ventricular (LV) diastolic dysfunction is increasingly common in heart failure with preserved ejection fraction (HFpEF), and new drug therapy is desired. We recently reported that dantrolene (DAN) attenuates pressure-overload induced hypertrophic signaling through stabilization of tetrameric st...

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Bibliographic Details
Main Authors: Junya Nawata, Takeshi Yamamoto, Shinji Tanaka, Yasutake Yano, Tomoyuki Uchida, Shohei Fujii, Yoshihide Nakamura, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Dantrolene
Calmodulin
Hypertrophy
HFpEF
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823000304

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