Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes.

Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes.

In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that overexpression of constitutively active FOXO1 decreases activin induction of murine Fshb gene expression in immortalized LβT2 cells. We demonstrate...

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Bibliographic Details
Main Authors: Chung Hyun Park, Danalea V Skarra, Alissa J Rivera, David J Arriola, Varykina G Thackray
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4244159?pdf=render

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