A population scale analysis of rare SNCA variation in the UK Biobank

A population scale analysis of rare SNCA variation in the UK Biobank

Parkinson's disease (PD) is a complex neurodegenerative disease with a variety of genetic and environmental factors contributing to disease. The SNCA gene encodes for the alpha-synuclein protein which plays a central role in PD, where aggregates of this protein are one of the pathological hallm...

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Bibliographic Details
Main Authors: Cornelis Blauwendraat, Mary B. Makarious, Hampton L. Leonard, Sara Bandres-Ciga, Hirotaka Iwaki, Mike A. Nalls, Alastair J. Noyce, Andrew B. Singleton
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
SNCA
Parkinson's disease
Copy number variants
Alpha-synuclein
Mosaicism
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304575

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