Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept

Tumor immune microenvironment-based therapies in pancreatic ductal adenocarcinoma: time to update the concept

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor immune microenvironment (TIME) formed by interactions among cancer cells, immune cells, cancer-associated fibroblasts (CAF), and extracellular matrix (ECM) components drives PDAC in a more immunosuppre...

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Bibliographic Details
Main Authors: Wenyu Luo, Ti Wen, Xiujuan Qu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic ductal adenocarcinoma
Tumor microenvironment
Immunophenotyping
Integrated therapy
Online Access:https://doi.org/10.1186/s13046-023-02935-3

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