Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France
(1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID is an observational retrospective study in <i>Nord Franche-Comté</i> Hospital in France that included adult COVID-19 patients confirmed by RT-PCR fr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/8/1719 |
| _version_ | 1797522781464690688 |
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| author | Souheil Zayet Hajer Zahra Pierre-Yves Royer Can Tipirdamaz Julien Mercier Vincent Gendrin Quentin Lepiller Solène Marty-Quinternet Molka Osman Nabil Belfeki Lynda Toko Pauline Garnier Alix Pierron Julie Plantin Louise Messin Marc Villemain Kevin Bouiller Timothée Klopfenstein |
| author_facet | Souheil Zayet Hajer Zahra Pierre-Yves Royer Can Tipirdamaz Julien Mercier Vincent Gendrin Quentin Lepiller Solène Marty-Quinternet Molka Osman Nabil Belfeki Lynda Toko Pauline Garnier Alix Pierron Julie Plantin Louise Messin Marc Villemain Kevin Bouiller Timothée Klopfenstein |
| author_sort | Souheil Zayet |
| collection | DOAJ |
| description | (1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID is an observational retrospective study in <i>Nord Franche-Comté</i> Hospital in France that included adult COVID-19 patients confirmed by RT-PCR from 1 March 2020 to 31 May 2020. The aim was to describe patients with post-COVID-19 syndrome with persistent symptoms (PS group) and to compare them with the patients without persistent symptoms (no-PS group). (3) Results. Of the 354 COVID-19 patients, 35.9% (<i>n</i> = 127) reported persistence of at least one symptom after a mean of 289.1 ± 24.5 days after symptom onset. Moreover, 115 patients reported a recurrence of symptoms after recovery, and only 12 patients reported continuous symptoms. The mean age of patients was 48.6 years (19–93) ± 19.4, and 81 patients (63.8%) were female. Patients in the PS group had a longer duration of symptoms of initial acute SARS-CoV-2 infection than patients in the no-PS group (respectively, 57.1 ± 82.1 days versus 29.7 ± 42.1 days, <i>p</i> < 0.001). A majority of patients (<i>n</i> = 104, 81.9%) reported three or more symptoms. The most prevalent persistent symptoms were loss of smell (74.0%, <i>n</i> = 94), fatigue (53.5%, <i>n</i> = 68), loss of taste (31.5%, <i>n</i> = 40), and dyspnea (30.7%, <i>n</i> = 39). These were followed by pain symptoms (26.8% (<i>n</i> = 34), 26.0% (<i>n</i> = 33), 24.4% (<i>n</i> = 31); headache, arthralgia, and myalgia, respectively). More than half of patients reporting persistent symptoms (58%, <i>n</i> = 73) were healthcare workers (HCWs). Among outpatients, this population was more present in the PS group than the no-PS group ((86.6%) <i>n</i> = 71/82 versus (72.2%) <i>n</i> = 109/151, <i>p</i> = 0.012). Post-COVID-19 syndrome was more frequent in patients with a past history of chronic rhinosinusitis (8.7% (<i>n</i> = 11%) versus 1.3% (<i>n</i> = 3), <i>p</i> < 0.001). No significant difference was found regarding clinical characteristics and outcome, laboratory, imaging findings, and treatment received in the two groups. (4) Conclusions. More than a third of our COVID-19 patients presented persistent symptoms after SARS-CoV-2 infection, particularly through loss of smell, loss of taste, fatigue, and dyspnea, with a high prevalence in HCWs among COVID-19 outpatients. |
| first_indexed | 2024-03-10T08:34:13Z |
| format | Article |
| id | doaj.art-723a4bf5223b475983706f85f6cb5ebf |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T08:34:13Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-723a4bf5223b475983706f85f6cb5ebf2023-11-22T08:47:52ZengMDPI AGMicroorganisms2076-26072021-08-0198171910.3390/microorganisms9081719Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, FranceSouheil Zayet0Hajer Zahra1Pierre-Yves Royer2Can Tipirdamaz3Julien Mercier4Vincent Gendrin5Quentin Lepiller6Solène Marty-Quinternet7Molka Osman8Nabil Belfeki9Lynda Toko10Pauline Garnier11Alix Pierron12Julie Plantin13Louise Messin14Marc Villemain15Kevin Bouiller16Timothée Klopfenstein17Infectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceDiabetology and Endocrinology Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceVirology Department, University Hospital of Besançon, 25000 Besançon, FranceVirology Department, University Hospital of Besançon, 25000 Besançon, FranceFaculty of Medicine of Tunis, University Tunis El Manar, Tunis 1007, TunisiaInternal Medicine Department, Groupe Hospitalier Sud Ile de France, 77000 Melun, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceMicrobiology Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceMicrobiology Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceMicrobiology Department, Nord Franche-Comté Hospital, 90400 Trevenans, FranceInfectious Disease Department, University Hospital of Besançon, 25000 Besançon, FranceInfectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, France(1) Background. Post-COVID-19 syndrome is defined as the persistence of symptoms after confirmed SARS-CoV-2 infection. (2) Methods. ANOSVID is an observational retrospective study in <i>Nord Franche-Comté</i> Hospital in France that included adult COVID-19 patients confirmed by RT-PCR from 1 March 2020 to 31 May 2020. The aim was to describe patients with post-COVID-19 syndrome with persistent symptoms (PS group) and to compare them with the patients without persistent symptoms (no-PS group). (3) Results. Of the 354 COVID-19 patients, 35.9% (<i>n</i> = 127) reported persistence of at least one symptom after a mean of 289.1 ± 24.5 days after symptom onset. Moreover, 115 patients reported a recurrence of symptoms after recovery, and only 12 patients reported continuous symptoms. The mean age of patients was 48.6 years (19–93) ± 19.4, and 81 patients (63.8%) were female. Patients in the PS group had a longer duration of symptoms of initial acute SARS-CoV-2 infection than patients in the no-PS group (respectively, 57.1 ± 82.1 days versus 29.7 ± 42.1 days, <i>p</i> < 0.001). A majority of patients (<i>n</i> = 104, 81.9%) reported three or more symptoms. The most prevalent persistent symptoms were loss of smell (74.0%, <i>n</i> = 94), fatigue (53.5%, <i>n</i> = 68), loss of taste (31.5%, <i>n</i> = 40), and dyspnea (30.7%, <i>n</i> = 39). These were followed by pain symptoms (26.8% (<i>n</i> = 34), 26.0% (<i>n</i> = 33), 24.4% (<i>n</i> = 31); headache, arthralgia, and myalgia, respectively). More than half of patients reporting persistent symptoms (58%, <i>n</i> = 73) were healthcare workers (HCWs). Among outpatients, this population was more present in the PS group than the no-PS group ((86.6%) <i>n</i> = 71/82 versus (72.2%) <i>n</i> = 109/151, <i>p</i> = 0.012). Post-COVID-19 syndrome was more frequent in patients with a past history of chronic rhinosinusitis (8.7% (<i>n</i> = 11%) versus 1.3% (<i>n</i> = 3), <i>p</i> < 0.001). No significant difference was found regarding clinical characteristics and outcome, laboratory, imaging findings, and treatment received in the two groups. (4) Conclusions. More than a third of our COVID-19 patients presented persistent symptoms after SARS-CoV-2 infection, particularly through loss of smell, loss of taste, fatigue, and dyspnea, with a high prevalence in HCWs among COVID-19 outpatients.https://www.mdpi.com/2076-2607/9/8/1719post-COVID-19long COVID-19follow-upfatiguedyspneahealth care workers |
| spellingShingle | Souheil Zayet Hajer Zahra Pierre-Yves Royer Can Tipirdamaz Julien Mercier Vincent Gendrin Quentin Lepiller Solène Marty-Quinternet Molka Osman Nabil Belfeki Lynda Toko Pauline Garnier Alix Pierron Julie Plantin Louise Messin Marc Villemain Kevin Bouiller Timothée Klopfenstein Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France Microorganisms post-COVID-19 long COVID-19 follow-up fatigue dyspnea health care workers |
| title | Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France |
| title_full | Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France |
| title_fullStr | Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France |
| title_full_unstemmed | Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France |
| title_short | Post-COVID-19 Syndrome: Nine Months after SARS-CoV-2 Infection in a Cohort of 354 Patients: Data from the First Wave of COVID-19 in Nord Franche-Comté Hospital, France |
| title_sort | post covid 19 syndrome nine months after sars cov 2 infection in a cohort of 354 patients data from the first wave of covid 19 in nord franche comte hospital france |
| topic | post-COVID-19 long COVID-19 follow-up fatigue dyspnea health care workers |
| url | https://www.mdpi.com/2076-2607/9/8/1719 |
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