Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain
The Gyrus ambiens is a gross anatomical prominence in the medial temporal lobe (MTL), associated closely with Brodmann area 34 (BA34). It is formed largely by the medial intermediate subfield of the entorhinal cortex (EC) [Brodmann area 28 (BA28)]. Although the MTL has been widely studied due to its...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-02-01
|
| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnana.2019.00021/full |
| _version_ | 1818194195945357312 |
|---|---|
| author | Ricardo Insausti Marta Córcoles-Parada Mar Maria Ubero Adriana Rodado Ana Maria Insausti Mónica Muñoz-López |
| author_facet | Ricardo Insausti Marta Córcoles-Parada Mar Maria Ubero Adriana Rodado Ana Maria Insausti Mónica Muñoz-López |
| author_sort | Ricardo Insausti |
| collection | DOAJ |
| description | The Gyrus ambiens is a gross anatomical prominence in the medial temporal lobe (MTL), associated closely with Brodmann area 34 (BA34). It is formed largely by the medial intermediate subfield of the entorhinal cortex (EC) [Brodmann area 28 (BA28)]. Although the MTL has been widely studied due to its well-known role on memory and spatial information, the anatomical relationship between G. ambiens, BA34, and medial intermediate EC subfield has not been completely defined, in particular whether BA34 is part of the EC or a different type of cortex. In order to clarify this issue, we carried out a detailed analysis of 37 human MTLs, determining the exact location of medial intermediate EC subfield and its extent within the G. ambiens, its cortical thickness, and the histological–MRI correspondence of the G. ambiens with the medial intermediate EC subfield in 10 ex vivo MRI. Our results show that the G. ambiens is limited between two small sulci in the medial aspect of the MTL, which correspond almost perfectly to the extent of the medial intermediate EC subfield, although the rostral and caudal extensions of the G. ambiens may extend to the olfactory (rostrally) and intermediate (caudally) entorhinal subfields. Moreover, the cortical thickness averaged 2.5 mm (1.3 mm for layers I–III and 1 mm for layers V–VI). Moreover, distance among different landmarks visible in the MRI scans which are relevant to the identification of the G. ambiens in MRI are provided. These results suggest that BA34 is a part of the EC that fits best with the medial intermediate subfield. The histological data, together with the ex vivo MRI identification and thickness of these structures may be of use when assessing changes in MRI scans in clinical settings, such as Alzheimer disease. |
| first_indexed | 2024-12-12T00:58:26Z |
| format | Article |
| id | doaj.art-723ad0e343a64d24aec8d30d7178260b |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-12T00:58:26Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-723ad0e343a64d24aec8d30d7178260b2022-12-22T00:43:48ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292019-02-011310.3389/fnana.2019.00021426478Cytoarchitectonic Areas of the Gyrus ambiens in the Human BrainRicardo Insausti0Marta Córcoles-Parada1Mar Maria Ubero2Adriana Rodado3Ana Maria Insausti4Mónica Muñoz-López5Human Neuroanatomy Laboratory, School of Medicine, University of Castilla–La Mancha, Albacete, SpainHuman Neuroanatomy Laboratory, School of Medicine, University of Castilla–La Mancha, Albacete, SpainDepartamento de Anatomía, Universidad Católica San Antonio de Murcia, Murcia, SpainHuman Neuroanatomy Laboratory, School of Medicine, University of Castilla–La Mancha, Albacete, SpainFaculty of Health Sciences, University Public of Navarra, Pamplona, SpainHuman Neuroanatomy Laboratory, School of Medicine, University of Castilla–La Mancha, Albacete, SpainThe Gyrus ambiens is a gross anatomical prominence in the medial temporal lobe (MTL), associated closely with Brodmann area 34 (BA34). It is formed largely by the medial intermediate subfield of the entorhinal cortex (EC) [Brodmann area 28 (BA28)]. Although the MTL has been widely studied due to its well-known role on memory and spatial information, the anatomical relationship between G. ambiens, BA34, and medial intermediate EC subfield has not been completely defined, in particular whether BA34 is part of the EC or a different type of cortex. In order to clarify this issue, we carried out a detailed analysis of 37 human MTLs, determining the exact location of medial intermediate EC subfield and its extent within the G. ambiens, its cortical thickness, and the histological–MRI correspondence of the G. ambiens with the medial intermediate EC subfield in 10 ex vivo MRI. Our results show that the G. ambiens is limited between two small sulci in the medial aspect of the MTL, which correspond almost perfectly to the extent of the medial intermediate EC subfield, although the rostral and caudal extensions of the G. ambiens may extend to the olfactory (rostrally) and intermediate (caudally) entorhinal subfields. Moreover, the cortical thickness averaged 2.5 mm (1.3 mm for layers I–III and 1 mm for layers V–VI). Moreover, distance among different landmarks visible in the MRI scans which are relevant to the identification of the G. ambiens in MRI are provided. These results suggest that BA34 is a part of the EC that fits best with the medial intermediate subfield. The histological data, together with the ex vivo MRI identification and thickness of these structures may be of use when assessing changes in MRI scans in clinical settings, such as Alzheimer disease.https://www.frontiersin.org/article/10.3389/fnana.2019.00021/fullhumanentorhinal cortexsubfield EMIambient gyruscytoarchitectonicsBA34 |
| spellingShingle | Ricardo Insausti Marta Córcoles-Parada Mar Maria Ubero Adriana Rodado Ana Maria Insausti Mónica Muñoz-López Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain Frontiers in Neuroanatomy human entorhinal cortex subfield EMI ambient gyrus cytoarchitectonics BA34 |
| title | Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain |
| title_full | Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain |
| title_fullStr | Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain |
| title_full_unstemmed | Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain |
| title_short | Cytoarchitectonic Areas of the Gyrus ambiens in the Human Brain |
| title_sort | cytoarchitectonic areas of the gyrus ambiens in the human brain |
| topic | human entorhinal cortex subfield EMI ambient gyrus cytoarchitectonics BA34 |
| url | https://www.frontiersin.org/article/10.3389/fnana.2019.00021/full |
| work_keys_str_mv | AT ricardoinsausti cytoarchitectonicareasofthegyrusambiensinthehumanbrain AT martacorcolesparada cytoarchitectonicareasofthegyrusambiensinthehumanbrain AT marmariaubero cytoarchitectonicareasofthegyrusambiensinthehumanbrain AT adrianarodado cytoarchitectonicareasofthegyrusambiensinthehumanbrain AT anamariainsausti cytoarchitectonicareasofthegyrusambiensinthehumanbrain AT monicamunozlopez cytoarchitectonicareasofthegyrusambiensinthehumanbrain |