Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy
Cow’s milk allergy is a common food allergy in infants, and is associated with an increased risk of developing other allergic diseases. Dietary selenium (Se), one of the essential micronutrients for humans and animals, is an important bioelement which can influence both innate and adaptive immune re...
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MDPI AG
2021-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/8/2479 |
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| author | Xiaoli Zhao Suzan Thijssen Hongbing Chen Johan Garssen Leon M. J. Knippels Astrid Hogenkamp |
| author_facet | Xiaoli Zhao Suzan Thijssen Hongbing Chen Johan Garssen Leon M. J. Knippels Astrid Hogenkamp |
| author_sort | Xiaoli Zhao |
| collection | DOAJ |
| description | Cow’s milk allergy is a common food allergy in infants, and is associated with an increased risk of developing other allergic diseases. Dietary selenium (Se), one of the essential micronutrients for humans and animals, is an important bioelement which can influence both innate and adaptive immune responses. However, the effects of Se on food allergy are still largely unknown. In the current study it was investigated whether dietary Se supplementation can inhibit whey-induced food allergy in an animal research model. Three-week-old female C3H/HeOuJ mice were intragastrically sensitized with whey protein and cholera toxin and randomly assigned to receive a control, low, medium or high Se diet. Acute allergic symptoms, allergen specific immunoglobulin (Ig) E levels and mast cell degranulation were determined upon whey challenge. Body temperature was significantly higher in mice that received the medium Se diet 60 min after the oral challenge with whey compared to the positive control group, which is indicative of impaired anaphylaxis. This was accompanied by reductions in antigen-specific immunoglobulins and reduced levels of mouse mast cell protease-1 (mMCP-1). This study demonstrates that oral Se supplementation may modulate allergic responses to whey by decreasing specific antibody responses and mMCP-1 release. |
| first_indexed | 2024-03-10T08:31:15Z |
| format | Article |
| id | doaj.art-723c392132d4468a9abc16a4c6de7645 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T08:31:15Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-723c392132d4468a9abc16a4c6de76452023-11-22T09:01:30ZengMDPI AGNutrients2072-66432021-07-01138247910.3390/nu13082479Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk AllergyXiaoli Zhao0Suzan Thijssen1Hongbing Chen2Johan Garssen3Leon M. J. Knippels4Astrid Hogenkamp5State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The NetherlandsState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, ChinaDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The NetherlandsDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, 3584 CG Utrecht, The NetherlandsCow’s milk allergy is a common food allergy in infants, and is associated with an increased risk of developing other allergic diseases. Dietary selenium (Se), one of the essential micronutrients for humans and animals, is an important bioelement which can influence both innate and adaptive immune responses. However, the effects of Se on food allergy are still largely unknown. In the current study it was investigated whether dietary Se supplementation can inhibit whey-induced food allergy in an animal research model. Three-week-old female C3H/HeOuJ mice were intragastrically sensitized with whey protein and cholera toxin and randomly assigned to receive a control, low, medium or high Se diet. Acute allergic symptoms, allergen specific immunoglobulin (Ig) E levels and mast cell degranulation were determined upon whey challenge. Body temperature was significantly higher in mice that received the medium Se diet 60 min after the oral challenge with whey compared to the positive control group, which is indicative of impaired anaphylaxis. This was accompanied by reductions in antigen-specific immunoglobulins and reduced levels of mouse mast cell protease-1 (mMCP-1). This study demonstrates that oral Se supplementation may modulate allergic responses to whey by decreasing specific antibody responses and mMCP-1 release.https://www.mdpi.com/2072-6643/13/8/2479seleno-l-methionineseleniumcow’s milk allergymouse modeldendritic cellsT cells |
| spellingShingle | Xiaoli Zhao Suzan Thijssen Hongbing Chen Johan Garssen Leon M. J. Knippels Astrid Hogenkamp Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy Nutrients seleno-l-methionine selenium cow’s milk allergy mouse model dendritic cells T cells |
| title | Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy |
| title_full | Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy |
| title_fullStr | Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy |
| title_full_unstemmed | Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy |
| title_short | Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow’s Milk Allergy |
| title_sort | selenium modulates the allergic response to whey protein in a mouse model for cow s milk allergy |
| topic | seleno-l-methionine selenium cow’s milk allergy mouse model dendritic cells T cells |
| url | https://www.mdpi.com/2072-6643/13/8/2479 |
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