Biomechanical stress in the context of competitive sports training triggers enthesitis
Abstract Objective To evaluate the influence of mechanical stress on the development of immediate enthesitis. Methods The BEAT study is an interventional study that assessed entheses in competitive badminton players before and immediately after a 60-min intensive training session. Power Doppler (PD)...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-06-01
|
| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13075-021-02530-x |
| _version_ | 1830473926735560704 |
|---|---|
| author | David Simon Arnd Kleyer Sara Bayat Johannes Knitza Larissa Valor-Mendez Marina Schweiger Georg Schett Koray Tascilar Axel J. Hueber |
| author_facet | David Simon Arnd Kleyer Sara Bayat Johannes Knitza Larissa Valor-Mendez Marina Schweiger Georg Schett Koray Tascilar Axel J. Hueber |
| author_sort | David Simon |
| collection | DOAJ |
| description | Abstract Objective To evaluate the influence of mechanical stress on the development of immediate enthesitis. Methods The BEAT study is an interventional study that assessed entheses in competitive badminton players before and immediately after a 60-min intensive training session. Power Doppler (PD) signal and Gray scale (GS) changes were assessed in the insertion sites of both Achilles tendon, patellar tendons, and lateral humeral epicondyles and quantified using a validated scoring system. Results Thirty-two badminton players were included. One hundred ninety-two entheseal sites were examined twice. The respective empirical total scores for PD examination were 0.1 (0.3) before and 0.5 (0.9) after training. Mean total GS scores were 2.9 (2.5) and 3.1 (2.5) before and after training, respectively. The mean total PD score difference of 0.4 between pre- and post-training was significant (p = 0.0014), whereas no significant difference for the mean total GS score was observed. Overall, seven participants (22%) showed an increased empirical total PD score. A mixed effects model showed a significant increase of PD scores after training, with a mean increase per site of 0.06 (95% CI 0.01 to 0.12, p = 0.017). Conclusions Mechanical stress leads to rapid inflammatory responses in the entheseal structures of humans. These data support the concept of mechanoinflammation in diseases associated with enthesitis. |
| first_indexed | 2024-12-21T15:09:56Z |
| format | Article |
| id | doaj.art-723c4ef5c778411ba31a1acded11de83 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-12-21T15:09:56Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-723c4ef5c778411ba31a1acded11de832022-12-21T18:59:19ZengBMCArthritis Research & Therapy1478-63622021-06-012311610.1186/s13075-021-02530-xBiomechanical stress in the context of competitive sports training triggers enthesitisDavid Simon0Arnd Kleyer1Sara Bayat2Johannes Knitza3Larissa Valor-Mendez4Marina Schweiger5Georg Schett6Koray Tascilar7Axel J. Hueber8Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum ErlangenAbstract Objective To evaluate the influence of mechanical stress on the development of immediate enthesitis. Methods The BEAT study is an interventional study that assessed entheses in competitive badminton players before and immediately after a 60-min intensive training session. Power Doppler (PD) signal and Gray scale (GS) changes were assessed in the insertion sites of both Achilles tendon, patellar tendons, and lateral humeral epicondyles and quantified using a validated scoring system. Results Thirty-two badminton players were included. One hundred ninety-two entheseal sites were examined twice. The respective empirical total scores for PD examination were 0.1 (0.3) before and 0.5 (0.9) after training. Mean total GS scores were 2.9 (2.5) and 3.1 (2.5) before and after training, respectively. The mean total PD score difference of 0.4 between pre- and post-training was significant (p = 0.0014), whereas no significant difference for the mean total GS score was observed. Overall, seven participants (22%) showed an increased empirical total PD score. A mixed effects model showed a significant increase of PD scores after training, with a mean increase per site of 0.06 (95% CI 0.01 to 0.12, p = 0.017). Conclusions Mechanical stress leads to rapid inflammatory responses in the entheseal structures of humans. These data support the concept of mechanoinflammation in diseases associated with enthesitis.https://doi.org/10.1186/s13075-021-02530-xEnthesitisBiomechanical stressInflammation |
| spellingShingle | David Simon Arnd Kleyer Sara Bayat Johannes Knitza Larissa Valor-Mendez Marina Schweiger Georg Schett Koray Tascilar Axel J. Hueber Biomechanical stress in the context of competitive sports training triggers enthesitis Arthritis Research & Therapy Enthesitis Biomechanical stress Inflammation |
| title | Biomechanical stress in the context of competitive sports training triggers enthesitis |
| title_full | Biomechanical stress in the context of competitive sports training triggers enthesitis |
| title_fullStr | Biomechanical stress in the context of competitive sports training triggers enthesitis |
| title_full_unstemmed | Biomechanical stress in the context of competitive sports training triggers enthesitis |
| title_short | Biomechanical stress in the context of competitive sports training triggers enthesitis |
| title_sort | biomechanical stress in the context of competitive sports training triggers enthesitis |
| topic | Enthesitis Biomechanical stress Inflammation |
| url | https://doi.org/10.1186/s13075-021-02530-x |
| work_keys_str_mv | AT davidsimon biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis AT arndkleyer biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis AT sarabayat biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis AT johannesknitza biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis AT larissavalormendez biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis AT marinaschweiger biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis AT georgschett biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis AT koraytascilar biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis AT axeljhueber biomechanicalstressinthecontextofcompetitivesportstrainingtriggersenthesitis |