Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphoma
Aim. Efficacy of the treatment of primary mediastinal B-cell lymphosarcoma depends to a great extent on early diagnosis and treatment policy. In this study we evaluated possibilities of diagnosis and treatment of thrombotic complications of primary mediastinal B-cell lymphosarcoma (PMBL). Material a...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2004-07-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29995 |
| _version_ | 1818097192254046208 |
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| author | В Т Dzhumabaeva A M Kremenetskaya S A Vasilyev E M Shulutko S K Kravchenko A A Shevelev E V Sergeeva Ya D Sakhibov E В Orel E A Romanova G A Frank |
| author_facet | В Т Dzhumabaeva A M Kremenetskaya S A Vasilyev E M Shulutko S K Kravchenko A A Shevelev E V Sergeeva Ya D Sakhibov E В Orel E A Romanova G A Frank |
| author_sort | В Т Dzhumabaeva |
| collection | DOAJ |
| description | Aim. Efficacy of the treatment of primary mediastinal B-cell lymphosarcoma depends to a great extent on early diagnosis and treatment policy. In this study we evaluated possibilities of diagnosis and treatment of thrombotic complications of primary mediastinal B-cell lymphosarcoma (PMBL). Material and methods. 61 patients were examined using roentgenography, computed tomography, chest ultrasound investigation,coagulogram, allelle specific polymerase chain reaction, ultrasound investigation of the jugular, subclavian, brachial veins, vena cava superior to detect mutation of genes II, Vfactors and methylentetrahydrofolatereductase.
Results. In 7 cases prechemotherapy examination detected thrombosis of the internal jugular and subclavian veins. In 4 of 7 cases there was a combined thrombosis of the left internal jugular and subclavian veins, in 3 cases one the vessels was affected with thrombosis. In 2 cases, in the course of polychemotherapy, there was recurrent thrombosis and development of pulmonary artery thromboembolism (PATE). In progression of the disease there was thrombosis of the left subclavian vein (1 case) and PA ТЕ (a case). Coagulologically, hypercoagulation syndrome signs were registered. 5 patients with PMBL complicated by thromboses showed gene mutations.
Conclusion. In PMBL there is a tendency to formation of venous thrombosis and development of PATE. This is explained by tumor process and hereditary factors of thrombogenicity. Therefore, specific antitumor treatment should include anticoagulation theerapy. |
| first_indexed | 2024-12-10T23:16:36Z |
| format | Article |
| id | doaj.art-723d6f7745d94fc8b42cc3d46fad2bee |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-10T23:16:36Z |
| publishDate | 2004-07-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-723d6f7745d94fc8b42cc3d46fad2bee2022-12-22T01:29:49Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422004-07-01797505427023Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphomaВ Т DzhumabaevaA M KremenetskayaS A VasilyevE M ShulutkoS K KravchenkoA A ShevelevE V SergeevaYa D SakhibovE В OrelE A RomanovaG A FrankAim. Efficacy of the treatment of primary mediastinal B-cell lymphosarcoma depends to a great extent on early diagnosis and treatment policy. In this study we evaluated possibilities of diagnosis and treatment of thrombotic complications of primary mediastinal B-cell lymphosarcoma (PMBL). Material and methods. 61 patients were examined using roentgenography, computed tomography, chest ultrasound investigation,coagulogram, allelle specific polymerase chain reaction, ultrasound investigation of the jugular, subclavian, brachial veins, vena cava superior to detect mutation of genes II, Vfactors and methylentetrahydrofolatereductase. Results. In 7 cases prechemotherapy examination detected thrombosis of the internal jugular and subclavian veins. In 4 of 7 cases there was a combined thrombosis of the left internal jugular and subclavian veins, in 3 cases one the vessels was affected with thrombosis. In 2 cases, in the course of polychemotherapy, there was recurrent thrombosis and development of pulmonary artery thromboembolism (PATE). In progression of the disease there was thrombosis of the left subclavian vein (1 case) and PA ТЕ (a case). Coagulologically, hypercoagulation syndrome signs were registered. 5 patients with PMBL complicated by thromboses showed gene mutations. Conclusion. In PMBL there is a tendency to formation of venous thrombosis and development of PATE. This is explained by tumor process and hereditary factors of thrombogenicity. Therefore, specific antitumor treatment should include anticoagulation theerapy.https://ter-arkhiv.ru/0040-3660/article/view/29995primary mediastinal b-cell lymphosarcomathrombosis of the jugular veinsthrombosis of the subclavian veinspulmonary artery thromboembolismactivated partial thromboplastic timeinternational standardsmethylentetrahydrofolatereductase geneprothrombin geneleiden's mutation |
| spellingShingle | В Т Dzhumabaeva A M Kremenetskaya S A Vasilyev E M Shulutko S K Kravchenko A A Shevelev E V Sergeeva Ya D Sakhibov E В Orel E A Romanova G A Frank Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphoma Терапевтический архив primary mediastinal b-cell lymphosarcoma thrombosis of the jugular veins thrombosis of the subclavian veins pulmonary artery thromboembolism activated partial thromboplastic time international standards methylentetrahydrofolatereductase gene prothrombin gene leiden's mutation |
| title | Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphoma |
| title_full | Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphoma |
| title_fullStr | Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphoma |
| title_full_unstemmed | Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphoma |
| title_short | Possibility of diagnosis and treatment of thrombotic complications in primary mediastinal B-cell lymphoma |
| title_sort | possibility of diagnosis and treatment of thrombotic complications in primary mediastinal b cell lymphoma |
| topic | primary mediastinal b-cell lymphosarcoma thrombosis of the jugular veins thrombosis of the subclavian veins pulmonary artery thromboembolism activated partial thromboplastic time international standards methylentetrahydrofolatereductase gene prothrombin gene leiden's mutation |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29995 |
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